A simple and effective tandem reaction
of diynones and allylic
alcohols was developed to afford functionalized 3-allyl-4-pyrones
in moderate to excellent yields. This protocol underwent a Michael
additionClaisen rearrangementO-cyclization process,
which exhibited broad substrate tolerance, high regioselectivity,
and atom economy under a metal-free
condition. Moreover, functional transformation of the products was
also further studied.
An effective annulation of ynones and (iso)quinoline N-oxides was developed to divergently prepare 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones under transition-metal-free conditions.
A transition-metal-free approach was developed to synthesize chromones from o-bromoaryl ynones and benzaldehyde oxime by sequential C–O bond formation.
A simple and effective annulation of ynediones and (iso)quinoline N-oxides was developed to afford various functionalized pyrrolo[2,1-a]isoquinolines and pyrrolo[1,2-a]quinolines in moderate to excellent yields. This protocol underwent a tandem [3 + 2] cycloaddition/ring-opening/N-nucleophilic addition, which exhibited high regioselectivity, broad substrate tolerance, and atom economy under catalyst-, additive-free, and air conditions. Moreover, indolizine was also successfully prepared using pyridine N-oxide.
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