In recent years, the processing of porous ceramic materials for implant applications has motivated the development and optimization of new technologies. To this purpose, a globular protein based (i.e. ovalbumin) consolidation approach has been proposed. In the present study, a porous hydroxyapatite:b-tricalcium phosphate - biphasic ceramics (BCP), was processed by consolidation using the protein-action technique. The processed ceramic materials exhibited appropriate pore configuration in terms of size, morphology and distribution. The in vitro reactivity and dissolution behavior of the ceramics was evaluated in SBF and biocompatibility in an osteoblasts culture, respectively. Overall, the materials tested showed biocompatibility and suitable properties for osteoconduction. A rough surface pattern displayed by the ceramics seemed to have improved both; cell adhesion and proliferation processes. In conclusion, this study revealed that the porous matrices obtained, promoted suitable development of cell metabolism without cellular death.
Summary: New synthetic polymeric membranes of lactic acid were prepared with different chemical composition through copolymerization with e-caprolactone and ethylene oxide segments. The prepared copolymers were characterized by hydrogen and carbon-13 nuclear magnetic resonance ( 1 H-NMR and 13 C-NMR) and presented wide range of mechanical properties demonstrated by dynamic mechanical thermal analysis (DMA). Porous membranes were prepared by dissolving the polymer in the presence of salts (NaCl or hydroxyapatite) and/or lower mass poly(ethylene glycol) (Mn ¼ 600 or 1,000 g Á mol
À1). The membranes presented new mechanical and biological characteristics and were suitable for cell penetration, anchorage, differentiation and proliferation. Adherence of cultured fibroblasts on membranes indicates biocompatibility.
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