Introduction: Keratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions commonly affecting the mandible bones. Langerhans cells (LCs) are specialized dendritic cells responsible for the presentation of antigens to T lymphocytes in mucosal and cutaneous surfaces. Objective: This study analyzed the immunohistochemical expression of LCs in KOTs. Material and method: Fifteen cases of KOTs were studied using the anti-CD1a marker. Results: LCs were observed in all 15 cases analyzed. They were found to be concentrated in areas of cystic epithelial hyperplasia, mainly in those areas presenting higher concentration of inflammatory cells. Furthermore, a significant association between the number of LCs and areas of cystic epithelium presenting hyperplasia (Mann-Whitney test, p = 0.0223) was observed. The shape and location of these cells in KOTs epithelium were variable. Conclusion: The lower number of LCs observed on atrophic cystic epithelium of KOTs may be due to decreased epithelial immunosurveillance and this may result in locally aggressive invasiveness.
Objectives:The aim of this study was to compare the subcutaneous tissue response to grey mineral trioxide aggregate white Sealapex plus zinc oxide. Methods: Polyethylene tubes filled with tested material were implanted in the connective tissue of rats. Control animals received empty tubes. Tissue samples were collected after 7, 60, and 90 days and stained with hematoxylin-eosin, picrosirius-fast green, and von Kossa stain for morphological analysis. The connective tissue response to the implanted materials was evaluated descriptively and semi-quantitatively by scoring the degree of inflammation, granulation tissue formation, fibrosis, and calcification. Results: Examinations of the grey mineral trioxide aggregate group over time revealed more intense inflammation at 7 days than at 60 days (p <0.05). In the Sealapex plus zinc oxide group, granulation tissue was more abundant at 7 days than at 60 days (p <0.05). Regarding calcification, von Kossa-positive granules were observed in the grey mineral trioxide aggregate and Sealapex plus zinc oxide groups at all time points studied. In the Sealapex/ZnO group, calcification was more apparent at 60 days than at 7 days (p <0.05). Relevance: This study demonstrates that all tested materials promote similar tissue reactions. Descriptors: Biocompatibility Testing, Endodontics, Dental Materials, Retrograde Obturation.
Objetivo: realizar uma revisão integrativa da literatura sobre os diferentes métodos que potencializam a desinfecção dos canais radiculares. Método: Trata-se de uma revisão integrativa, onde foram selecionados artigos nas bases de dados Pubmed e Scielo, utilizando os decritores Desinfecção”, “Endodontia” e “Enterococcus Faecalis” e seus respectivos termos em inglês: “Disinfection”, “Endodontics” e “Enterococcus Faecalis”, publicados nos últimos 10 anos. Resultados: Foram selecionados 09 artigos que foram lidos e seus achados sumarizados em formato de tabela, desses 06 estudos avaliaram a Irrigação Ultrassônica Passiva (PUI), apresentando os melhores resultados em 03 desses estudos. Conclusão: A desinfecção do canal radicular na presença dos métodos auxiliares foi superior em todos os estudos a limpeza promovida somente através dos instrumentos endodônticos, sejam eles manuais ou automatizados associado à solução irrigadora. Dentre os métodos estudados a PUI foi a mais utilizada, apresentando ainda resultados controversos, assim, torna-se necessário mais pesquisas acerca da temática.
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