Pleural effusion can be a complication of pancreatic diseases. Pancreaticopleural fistula (PPF) is a rare complication arising as a result of chronic pancreatitis that causes recurrent pleural effusions often resistant to thoracentesis. Diagnosis of PPF can be delayed, and presentation with respiratory symptoms related to pleural effusion is common. Elevated pleural fluid amylase and lipase levels are always helpful, but final diagnosis mostly requires demonstration of fistula on imaging modalities, such as computed tomography (CT) scan or magnetic resonance cholangiopancreatography (MRCP). Endoscopic retrograde cholangiopancreatography (ERCP) serves as a diagnostic and therapeutic tool. Here, we present a case of PPF leading to recurrent pleural effusions, treated with stent placement.
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