Dedicated to Prof. Gordon Gribble on the occasion of his retirement and for his outstanding contributions to science and mentoring of students.Received 12-23-2017 Accepted 02-17-2018 Published on line 03-04-2018
AbstractLignans are a class of compounds found in plants, especially fiber-rich foods such as flax seeds, whole grains, berries and vegetables. A diet rich in lignans is believed to be protective against cancer, inflammation, viral infection, stroke, and cardiovascular diseases. Enterolactone, a mammalian lignan, has been investigated extensively due to its potential therapeutic properties. A variety of approaches to synthesize enterolactone have been reported. This account summarizes some of the biological studies and reported syntheses of enterolactone found in literature.
Expanded substrate scope• Enantioselective catalytic method that access cyclopropyl rings containing hindered all-carbon quaternary chiral centers via Michael-Initiated Ring Closure reaction was successfully developed. • Expanding the substrate scope to various scaffolds including α,β-unsaturated carbonyls, N-heterocycles, and amides is currently in progress.The authors thank the Department of Chemistry and Biochemistry at NDSU for the generous financial support.
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