This study is based on an environmental assessment of acetylsalicylic acid and naproxen in waste and tap water samples of twenty different locations of municipal area of Sukkur city, Sindh, Pakistan. Both drugs belong to the most frequently used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) group. The specified pharmaceuticals were extracted from the wastewater and tap water samples by Solid Phase Extraction (SPE) method using Waters Oasis hydrophilic lipophilic balance (HLB) cartridges. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technique was applied for the detection and quantification of selected drugs. Negative Electron Spray Ionization (ESI) was used along with Multi Reaction Monitoring (MRM) mode. Pharmaceuticals concentration were found 7.38-827 µg/L and 5.47-328.95 µg/L in waste and tap water samples, respectively. The results obtained are comparable with the data reported in literature. Human health risk assessment caused by acetylsalicylic acid and naproxen in aquatic media was observed by applying Risk Quotient (RQ) approach. The calculated RQ values are low enough (order of 10-3 to 10-5) to cause a direct risk for consumers, but their presence in water may pose a danger synergistically.

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Introduction: Portal hypertensive gastropathy is a term applied to the typical appearance of the mucosa of stomach consisting of a mosaic-like diffuse and reticular cobblestone pattern of gastric mucosal layer secondary to increased blood pressure in the portal vein. Objective: To determine the occurrence and characteristic of portal hypertensive gastropathy in patients with liver cirrhosis Methodology: This study was descriptive cross-sectional piloted at the department of Medicine, Hayatabad medical complex Peshawar for duration of six months from November 2020 to May 2021. A total of 158 patients were observed in our study. All the data was entered and analyzed in SPSS version 21. Results: In our study portal Hypertensive Gastropathy was observed in 34(21.5%) cirrhosis patients while it was not observed in 124(78.5%) patients. Based on the class of portal hypertensive gastropathy, severe and mild types were observed in 43(27.2%) and 115(72.8%) patients respectively. Conclusion: In our study portal hypertensive gastropathy was observed in 34(21.5%) cirrhotic patients, amongst these 27.2% were severe and 72.8% were mild types. In cirrhotic and portal hypertensive gastropathy patients, these findings might have major therapeutic implications. Keywords: Frequency; Portal Hypertensive Gastropathy, Liver cirrhosis