Background: Catheter related blood stream infection (CRBSI) is a complication of central venous catheter (CVC) use. This Infection particularly in the ICU population results in higher levels of morbidity and mortality coupled with greater costs in terms of care and increased duration of hospital stay. Aim & Objectives: The aim of this study is to improve the safety of patients with CVC via decreasing the incidence of CRBSI in ICUs patients at Zagazig University Hospital through the following objectives: 1-Calculation the incidences of CRBSI in ICUs patients over six months before and after intervention through active surveillance. 2-Assessment the level of the knowledge and adherence of health care providers in ICUs to evidence based guidelines recommended by CDC to decrease the incidences of CRBSI in ICUs patients before and after intervention. 3-Implementation of health education program on ICUs health care providers i.e. providing them by information about evidence based guidelines recommended by CDC to decrease the incidence of CRBSI in ICUs patients.