Purpose Despite several new treatment options, single- and multi-institution analyses have not clarified whether survival patterns in follicular lymphoma (FL) patients have changed in recent decades. We undertook a study using a large population-based registry to analyze survival patterns among patients with FL. Patients and Methods Surveillance, Epidemiology, and End Results morphology codes were used to identify 14,564 patients diagnosed with FL between 1978 and 1999. Observed median survival times, Kaplan-Meier survival curves, proportional death hazard ratios, and relative survival rates were calculated. Joinpoint regression analysis was used to identify trends in annual adjusted death hazard ratios. Results An improvement in survival of all patients with FL was observed between each of three diagnosis eras (1978 to 1985, 1986 to 1992, and 1993 to 1999) by log-rank tests. Among patients with stage-specific data, the median survival time improved from 84 months (95% CI, 81 to 88 months) in the 1983 to 1989 era to 93 months (95% CI, 89 to 97 months) in the 1993 to 1999 era. Similar findings were identified across sex and age groups and for subsets including advanced-stage, large-cell FL and the combined subset of small cleaved- and mixed-cell FL. The inter-era survival advantage observed in white patients was not observed for black patients. The relative risk of death decreased by 1.8% per year over the 1983 to 1999 observation period. Conclusion The survival of patients with FL in the United States has improved over the last 25 years. The survival improvement may be a result of the sequential application of effective therapies and improved supportive care.

papilloma inverted squamous carcinoma squamous cell line SSC How to Cite this Article Swenson W Miller KA Wuertz B et al Establishment and characterization of an inverted papilloma-associated sinonasal squamous cell carcinoma cell line Int Forum Allergy Rhinol https //doi org/ /alr

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e18503 Background: This study examines the geographic distribution of clinical trials for common types of metastatic cancer in the United States and the accessibility of these trials to the general population. Methods: We accessed the ClinicalTrials.gov website and conducted a search for interventional clinical trials that were actively recruiting patients for diagnoses of metastatic lung, colon, pancreas, breast, and prostate cancers on November 25, 2022. We identified unique zip codes for all the clinical trials offered and calculated the U.S. population living within 50 miles of a clinical trial site using geographic information system software based on 2020 census data. We created maps for each cancer type, demonstrating the geographic distribution of clinical trial access in the United States. Results: We found a significant number of clinical trials providing access for most Americans diagnosed with the most common types of metastatic cancer. The majority of the United States population lives within 50 miles of a clinical trial. The access varied by cancer type studied, from 75.0% of the United States population for metastatic colon cancer to 90.2% for metastatic lung and breast cancers. See table for details. Conclusions: When considering the accessibility of these trials, we found that a large proportion of the United States population lived within 50 miles of a clinical trial site. This suggests that while many clinical trials are available, they may not be evenly distributed across the country and may not be accessible to all individuals. [Table: see text]

e17512 Background: Cancer awareness month campaigns are a health promotion tool used to increase public awareness about a specific cancer, its prevention, and treatment. Cancer awareness month campaigns could be most impactful in promoting awareness of cancers for which established screening guidelines exist. Currently, the United States Preventive Task Force endorses screening the general population for colon, cervical and breast cancers. We aimed to assess the effectiveness of campaigns by identifying internet search volume and monthly cancer diagnoses. Methods: GoogleTrends was utilized to identify the relative monthly volume of search terms from 2004 to 2009 as a proxy for public awareness. Search trends for“breast cancer”, “colon cancer”, and “cervical cancer” were analyzed and an average monthly search volume index (SVI) was determined. Surveillance, Epidemiology and End Result (SEER) data was analyzed during the same time period. These data were compared using Pearson's correlation coefficient and the chi square test for seasonality. The monthly trends were compared to corresponding cancer awareness month campaigns (breast cancer-October, colon cancer-March, cervical cancer-January). Results: Internet search volume was highest for colon cancer and breast cancer in the respective cancer awareness campaign months. The frequencies of breast cancer and colon cancer diagnoseswere not significantly higher in the respective cancer awareness months. Cervical cancer search volume and cancer diagnoses did not correlate with awareness campaign months. Search volume and cancer diagnoses were not well correlated for breast cancer (r=0.089) or cervical cancer (r=0.228); however, they were significantly correlated for colon cancer (r=0.386; p-value=0.0008). Conclusions: Cancer awareness month campaigns appear to raise public awareness as estimated by internet search volume for breast cancer and colon cancer. Cervical cancer awareness month campaigns do not have the same effect. There is no significant correlation between cancer awareness campaign months and cancer diagnosis incidence for either breast cancer or cervical cancer, whereas there is a significant correlation for colon cancer.

e18500 Background: A recent review of the medical literature of rural health cancer care delivery has not been published. We conducted a preliminary review of the last twenty years of rural health cancer care delivery literature utilizing medical subject headings (MeSH) within the PubMed NCBI) database. Methods: Using PubMed MeSH Major Topic terms “rural population” and “cancer” we identified publications published from 2000 to 2020. We searched PubMed for publications that included the major topic MeSH terms “rural population” and “cancer”. We individually reviewed articles, confirmed the focus of the article, and subcategorized the articles. Results: We identified 580 publications which met the search criteria, the majority were focused on the United States (266), followed by China (56), Australia (54), and India (27). Among the publications focusing on the United States, 76 involved Appalachian States. Kentucky (18) and Georgia (10) were the states most frequently represented. Malignancies most commonly represented were: breast cancer (148), uterine/cervical (84), and colorectal cancers (68). The journals which published the most rural health cancer care delivery were The Journal of Rural Health (42), Asian Pacific Journal of Cancer Prevention (20), Cancer (14), Rural and Remote Health (13), Journal of Cancer Education (13), Australian Journal of Rural Health (12). Conclusions: The rural health cancer care literature in the last two decades focuses primarily on the United States, China, Australia, and India. Within the United States, the research focus is Appalachia. The majority of articles focus on breast cancer, uterine/cervical, and colorectal cancers. The journal which published the majority of rural health cancer care articles was the Journal of Rural Health.

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9034 Background: Adjuvant radiotherapy after breast-conserving surgery is a standard therapy for invasive breast carcinoma. Controversy exists regarding the benefit of adjuvant radiotherapy for elderly women with favorable prognosis tumors. Methods: Using data from the Surveillance Epidemiology and End Results (SEER) registry, data were analyzed for 28,808 women ages = 65 years, with stage I and II, who underwent breast conservation therapy between 1998 and 2002. Relative survival rates (observed survival/expected survival) were calculated using Kaplan-Meier method for women who underwent radiotherapy and those for whom radiotherapy was omitted. Results: Among women = 65 years with stage I breast cancer who underwent breast conserving surgery (n = 20,400), 71.7% received adjuvant radiotherapy. Among those with stage II breast cancer (n = 8,408), 66.0% received adjuvant radiotherapy. Five-year relative survival rates among stage I patients were 1.000 (95% CI: 0.990, 1.010) for those receiving adjuvant radiotherapy, and 0.959 (95% CI: 0.932, 0.986) for those without adjuvant radiotherapy. Among stage II patients, the 5-year survival rates were 0.998 (95% CI: 0.978, 1.018) for those receiving adjuvant radiotherapy, and 0.832 (95% CI: 0.791, 0.873) for those without adjuvant radiotherapy. Conclusions: Adjuvant radiotherapy following breast conserving surgery may be safely omitted for elderly women with stage I breast carcinoma, especially for women ages 85–94 years. [Table: see text] No significant financial relationships to disclose.