Versatile Video Coding (VVC), a.k.a. ITU-T H.266 | ISO/IEC 23090-3, is the new generation video coding standard that has just been finalized by the Joint Video Experts Team (JVET) of ITU-T VCEG and ISO/IEC MPEG at its 19 th meeting ending on July 1, 2020. This paper gives an overview of the VVC high-level syntax (HLS), which forms its system and transport interface. Comparisons to the HLS designs in High Efficiency Video Coding (HEVC) and Advanced Video Coding (AVC), the previous major video coding standards, are included. When discussing new HLS features introduced into VVC or differences relative to HEVC and AVC, the reasoning behind the design differences and the benefits they bring are described. The HLS of VVC enables newer and more versatile use cases such as video region extraction, composition and merging of content from multiple coded video bitstreams, and viewport-adaptive 360 • immersive media.
Quantitative tools to assess vascular macromolecular distributions have been limited by low signal-to-noise ratios, reduced spatial resolution, postexperimental motion artifact, and the inability to provide multidimensional drug distribution profiles. Fluorescence microscopy offers the potential of identifying exogenous compounds within intact tissue by reducing autofluorescence, the process by which endogenous compounds emit energy at the same wavelength as fluorescent labels. A new technique combining fluorescence microscopy with digital postprocessing has been developed to address these limitations and is now described in detail. As a demonstration, histologic cross-sections of calf carotid arteries that had been loaded endovascularly with FITC-Dextran (20 kD) ex vivo were imaged at two different locations of the electromagnetic spectrum, one exciting only autofluorescent structures and the other exciting both autofluorescent elements and exogenous fluorescent labels. The former image was used to estimate the autofluorescence in the latter. Subtraction of the estimated autofluorescence resulted in an autofluorescence-corrected image. A standard curve, constructed from arteries that were incubated until equilibrium in different bulk phase concentrations of FITC-Dextran, was used to convert fluorescent intensities to tissue concentrations. This resulted in a concentration map with spatial resolution superior to many of the previous methods used to quantify macromolecular distributions. The transvascular concentration profiles measured by quantitative fluorescence microscopy compared favorably with those generated from the proven en face serial sectioning technique, validating the former. In addition, the fluorescence method demonstrated markedly increased spatial resolution. This new technique may well prove to be a valuable tool for elucidating the mechanisms of macromolecular transport, and for the rational design of drug delivery systems.
This paper proposes a novel wireless force measurement system for the Total Knee Arthroplasty (TKA) to improve the ligament balancing procedure during TKA. The force measurement system is comprised of a Wireless Force Measurement Spacer (WFMS) and the display part. They communicate with each other by the Radio Frequency (RF) signal. The WFMS is designed to measure the force between the WFMS and the femoral component of the artificial implants and to transmit the force data wirelessly by a low power transceiver. The display part demonstrates the force data in 3D images in real time. The WFMS composes of a sensors array, a Universal Transducer Interfaces (UTIs) array, a low-power sub-threshold microprocessor and a transceiver. The sub-threshold 8-bit microprocessor is taped out with 0.18 microm CMOS technology. The testing results of the microprocessor show that the leakage power of 46nW and the dynamic power of 385nW@165kHz are achieved with the operating voltage of 350 mV. The test results of the system are given and the errors of the system are analyzed. The results verified the reliability of the system. The future work is to design the microprocessor and a lower power transceiver within a single chip.
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