Rabbit muscle GAPDH (E.C.1.2.1.12) was inhibited by two preparations of FSH, one ovine and the other porcine. A third preparation, also of ovine origin, did not inhibit this enzyme. This suggested that the inhibition was not due to FSH but a contaminant. This inhibition of glyceraldehyde-3phosphate dehydrogenase was specific. None of the other pituitary hormones had any effect on this enzyme and other NAD-linked and NADP-linked dehydrogenases were not inhibited by these FSH preparations.
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