In this paper, a novel method is proposed for carrierfrequency offset (CFO) estimation for multi-user in orthogonal frequency division multiple access (OFDMA) uplink. Generalized carrier assignment scheme (GCAS) is supported in order to allow dynamic resource allocation and provide more flexility. The base station is equipped with multi-antenna. Each user's CFO can be estimated by a closed form based on ESPRIT-like method utilizing the rotation invariance of the space-domain snapshot matrix. The method is still effective even in fully loaded system with all subcarriers allocated to users, and the computational complexity can be adjusted dynamically according to the system assignment scheme.
Polymorphism of CYP2C19 was significantly associated with plasma concentration ratios of clopidogrel to its inactive metabolite SR26334. Clopidogrel metabolism was regulated by CYP2C19. The *2 and *3 allele carriage were independently associated with the antiplatelet effect of chronic clopidogrel therapy.
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