Gestational chorionepithelioma is the most tantalising of all neoplasms. Its life history is known with a degree of accuracy rarely obtainable in other neoplasms, for it can start only after fertil¬ isation of the ovum: it shows at times a spontaneous regression that betrays its intrinsic curability in other patients could we but reproduce in them the appropriate humoral climate: and it has a unique association with hydatidiform mole. Just because it has so many peculiarities of behaviour of this kind it ought, one feels, to be so much the more susceptible to investigation, and with greater hope of success, than other more orthodox neoplasms. One of its striking peculiarities is its ability to kill by metastasis yet show no source of origin within the uterus. Chorionepitheliomas of this type were early recognised, and the demonstration in 1893 by Dr. (later Professor) Georg Schmorl of Leipzig that particles of apparent trophoblast could be found with great frequency in the lungs of pregnant women at once raised the question: did chorionepitheliomas of this type arise by malignant transformation of placental emboli like these, or were the malignant foci in the lungs of these patients true metastases from a primary

Gestational chorionepithelioma is the most tantalising of all neoplasms. Its life history is known with a degree of accuracy rarely obtainable in other neoplasms, for it can start only after fertil¬ isation of the ovum: it shows at times a spontaneous regression that betrays its intrinsic curability in other patients could we but reproduce in them the appropriate humoral climate: and it has a unique association with hydatidiform mole. Just because it has so many peculiarities of behaviour of this kind it ought, one feels, to be so much the more susceptible to investigation, and with greater hope of success, than other more orthodox neoplasms. One of its striking peculiarities is its ability to kill by metastasis yet show no source of origin within the uterus. Chorionepitheliomas of this type were early recognised, and the demonstration in 1893 by Dr. (later Professor) Georg Schmorl of Leipzig that particles of apparent trophoblast could be found with great frequency in the lungs of pregnant women at once raised the question: did chorionepitheliomas of this type arise by malignant transformation of placental emboli like these, or were the malignant foci in the lungs of these patients true metastases from a primary

1. A case of chondromyxoid fibroma of the tibia is reported. 2. Initial removal by curettage was followed by regrowth of residual foci; these were removed by a second curettage three years later. Re-examination after a further three years shows no evidence of regrowth, and suggests that cure has been achieved. 3. Some histological features of the neoplasm are briefly described.

No abstract