Aescoket | is an injection containing I[.54% (w/v) Ketamine Hydrochlorlde and 0.01% (w/v) Benzethonium Chloride in water. Both compounds could be analyzed by an HPLC system consisting of a silicagel column, dimensions 0.26 x 25 cm, particle size |0 ~m, a mobile phase of tetrabutylammonium bromide 0.[ M + dlsodlum hydrogen citrate 0.0[ M + water + methanol (i0 + 50 + 120 + 320, all by volume). Analysis of Ketamine was performed without sample clean-up; detection was performed at 219 nm. Results were compared with an assay according to Ketamine Hydrochloride injection USP XXI; the results correlated well. Benzethonium was extracted as an ion-pair with chloride into chloroform. After evaporation of the chloroform layer, the residue was redissolved in mobile phase and injected. Detection was performed at 225 nm. A stability study indicated an expiration date of two years after production by storage at room temperature.
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