The external region of a cell membrane, known as the glycocalyx, is dominated by glycosylated molecules, which direct specific interactions such as cell-cell recognition and contribute to the steric repulsion that prevents undesirable non-specific adhesion of other molecules and cells. Mimicking the non-adhesive properties of a glycocalyx provides a potential solution to the clinical problems, such as thrombosis, that are associated with implantable devices owing to non-specific adsorption of plasma proteins. Here we describe a biomimetic surface modification of graphite using oligosaccharide surfactant polymers, which, like a glycocalyx, provides a dense and confluent layer of oligosaccharides. The surfactant polymers consist of a flexible poly(vinyl amine) with dextran and alkanoyl side chains. We show that alkanoyl side chains assemble on graphite through hydrophobic interaction and epitaxial adsorption. This constrains the polymer backbone to lie parallel to the substrate, with solvated dextran side chains protruding into the aqueous phase, creating a glycocalyx-like coating. The resulting biomimetic surface is effective in suppressing protein adsorption from human plasma protein solution.

SCUBA-2 is a 10000-bolometer submillimetre camera on the James Clerk Maxwell Telescope (JCMT). The instrument commissioning was completed in September 2011, and full science operations began in October 2011. To harness the full potential of this powerful new astronomical tool, the instrument calibration must be accurate and well understood. To this end, the algorithms for calculating the line-of-sight opacity have been improved, and the derived atmospheric extinction relationships at both wavebands of the SCUBA-2 instrument are presented. The results from over 500 primary and secondary calibrator observations have allowed accurate determination of the flux conversion factors (FCF) for the 850 and 450 µm arrays. Descriptions of the instrument beam-shape and photometry methods are presented. The calibration factors are well determined, with relative calibration accuracy better than 5 per cent at 850 µm and 10 per cent at 450 µm, reflecting the success of the derived opacity relations as well as the stability of the performance of the instrument over several months. The sample-size of the calibration observations and accurate FCFs have allowed the determination of the 850 and 450 µm fluxes of several well-known submillimetre sources, and these results are compared with previous measurements from SCUBA.

The Submillimetre Common User Bolometer Array 2 (SCUBA-2) is an instrument operating on the 15-m James Clerk Maxwell Telescope, nominally consisting of 5120 bolometers in each of two simultaneous imaging bands centred over 450 and 850 µm. The camera is operated by scanning across the sky and recording data at a rate of 200 Hz. As the largest of a new generation of multiplexed kilopixel bolometer cameras operating in the (sub)millimetre, SCUBA-2 data analysis represents a significant challenge. We describe the production of maps using the Sub-Millimetre User Reduction Facility (SMURF) in which we have adopted a fast, iterative approach to map-making that enables data reduction on single, modern, high-end desktop computers, with execution times that are typically shorter than the observing times. SMURF is used in an automated setting, both at the telescope for real-time feedback to observers, as well as for the production of science products for the JCMT Science Archive at the Canadian Astronomy Data Centre. Three detailed case studies are used to: (i) explore convergence properties of the map-maker using simple prior constraints (Uranus -a point source); (ii) achieve the white-noise limit for faint point-source studies (extragalactic blank-field survey of the Lockman Hole); and (iii) demonstrate that our strategy is capable of recovering angular scales comparable to the size of the array footprint (approximately 5 arcmin) for bright extended sources (star-forming region M17).