We report the antibiofilm activity by the sponge-associated bacterium Cobetia marina upon Staphylococcus epidermidis clinical isolates obtained from central venous catheters. Antibiofilm activity/antimicrobial susceptibility correlation might predict the action of the metabolite(s) upon Staphylococcus epidermidis in the clinic, making it a possible adjuvant in therapies against biofilm-associated infections.Key words: biofilms, antibiofilm activity, Staphylococcus epidermidis, Cobetia marina, Darwinella sp.Medical device-related infections represent a serious clinical problem, since the majority of hospital patients undergo procedures for the insertion of foreign devices. Indeed, staphylococcal implant-related infections are the prototype of a biofilm infection and coagulase-negative staphylococci, mainly Staphylococcus epidermidis, predominate as the agent of these biomedical infections (11,12). Once the biofilm is established, therapeutic options become limited due to difficulties with the perfusion of antimicrobial agents into biofilm and to the metabolic latent state of bacteria in the biofilm lifestyle. Thus, interference with cell-cell signaling by modulating quorum sensing (QS) to prevent biofilm formation might be an attractive strategy to treat these infections. In this alternative approach, which does not interfere with bacterial growth, the switching off of virulence expression and attenuation of the pathogen make microorganisms more susceptible to antimicrobials and to the immune system (9).The potential advantages of antivirulence therapies include the large number of bacterial functions that can be inhibited, the preservation of normal human microbiota and the reduction in selective pressure that may result in decreased resistance (4).Marine sponges are reservoirs of microorganisms and their survival in this particular environment resulted in the ability to produce unique compounds as a manner of combating enemies (16), an ability which we wanted to exploit in order to target pathogenic biofilms. To our knowledge this is the first report on the production of culture filtrate obtained from the marine Gramnegative bacterium Cobetia marina, which interferes significantly in S. epidermidis biofilm formation.
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