The alcoholic extract of the leaves of Eriobotryajaponica was administered in doses of 100, 150, and 200 mg/kg body weight to normal and alloxan-diabetic rabbits. The blood glucose levels were estimated before and 1,2,3, and 4 hours after the administration of the extract. The extract exerted a significant (P <0.05) hypoglycaemic effect in normal rabbits which was, however, short-lived. The hypoglycaemic effect was not significant (P> 0.1) in alloxan-treated rabbits. The doses used did not show acute toxicity or result in behavioural changes. From this study, it may be concluded that the extract acts by initiating the release of insulin from pancratic beta cells of normal rabbits.The present work has been undertaken with the aim to study the effect of the alcoholic extract of the leaves of Eriobotrya japonica on the blood glucose levels of normal and alloxantreated, diabetic male rabbits. Acute toxicity and behavioural changes were also studied to check the safety of these doses. Materials and MethodsExperiments were performed on male, adult rabbits of a local strain weighing 0.52-1.65 kg. They were fed on green vegetables and grains and allowed tap-water ad libitum. ChemicalsAlloxan monohydrate was supplied by B. D. H. Laboratories (Chemical Division), Poole, England; o-toluidine, glacial acetic acid, thiourea, and trichloroacetic acid were obtained from E. Merck, Darmstadt, West Germany; tolbutamide was provided by Hoechst, West Germany. Preparation of ExtractThe alcoholic extract was prepared by the method described by Noreen et al. (2). The fresh leaves obtained from local trees were dried in the shade and the completely dried leaves were powdered with an electric grinder. The powder was extracted for 8 hours with petroleum ether to give a brown residue. Continued extraction with 95 % alcohol gave a Downloaded by: National University of Singapore. Copyrighted material.
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