Persistent pulmonary hypertension often occurs in infants with meconium aspiration syndrome or asphyxia. There is a subgroup of infants with PPHN in whom myocardiopathy predominates. We reviewed t h e course of 7 infants treated for PPHN who had increased heart size on chest x-ray, and/or an EKG with right ventricular hypertrophy. All patients had documented right-to-left shunting by echocardiogram either through PDA or foramen ovale. Mean B.W. was 3.13 + .49 kg SD (range 2.32 t o 3.74), G.A. was 38.85 5 2.38 weeks SD, Apgars mean of 4.71 2 2.49 SD a t one minute and 6.57 + 2.43 SD a t five minutes. All patients required 790% inspired oxygen concentration, with 6 patients on 100% requiring mechanical ventilation. The following were mean ventilator settings on day one: FiO2 98.57% + 3.77 SD, r a t e 87 + 34.95 SD bpm,
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