This study indicates an avenue for research for developing a novel class of antineoplastic compounds that can be synthesized using an easy, economical method.
The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common causes of FDE is the use of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams are in the NSAID group and piroxicam is one of the most used of these drugs. FDE caused by piroxicam is rare but a few cases have been reported. Patch tests are useful for diagnosing some cases of FDE; they give variable results on previously affected skin while no reaction appears on unaffected skin. Some cases of cross-sensitivity among piroxicam and other substances have been reported. We report two new cases of FDE due to piroxicam with negative patch test on normal skin and positive results on affected skin.
Oligonucleotide HLA typing (SSO) and Sequence-Specific Primer HLA typing (SSP). The results of typing were compared using χ 2 to those found by 250 healthy adult donors from the bone marrow bank of Northern Greece.Results: Three of our patients were HLA-DRB1*11 (DR11)/HLA-DQB1* 03 (DQ7) positive (5/10 haplotypes). The high frequency of HLA-DR11/DQ7 combination among our patients (50%) differed not significantly from the observed frequency of this combination among healthy individuals (21%) (p = 0.04 but after using Yate's correction p = 0.09). Τwo of our patients displaying this HLA combination were treated with ABVD for cHD and developed DLBCL nine and three years after diagnosis of cHL respectively. Both patients are alive and in remission for both lymphomas. The third HLADR11/DQ7+ patient was treated with CHOP for DLBCL and developed cHL 21 years after diagnosis of primary DLBCL. Interestingly while being in remission for both lymphomas she additionally developed mycosis fungoides displaying finally diagnoses of three sequential lymphomas. Conclusions:Although not reaching statistical significance due to small number of cases our results suggest that HLA analysis may be a field of investigational interest regarding patients with sequential lymphomas. HLA -DR11 has been previously reported as a risk factor for cHL irrespectively from EBV status. Importantly HLA-DQ7 is involved in the pathogenesis of autoimmune diseases. Interestingly HLA-DR11/DQ7 combination has been previously reported in association with vulvar lichen sclerosus and asthma. Of note this combination was also described in one case of familial systemic sclerosis following exposure to organic solvent. In conclusion our results emphasize the necessity for collecting and investigating sequential lymphomas in order to elucidate the underlying contributory mechanisms in the pathogenesis of lymphoproliferative diseases.
Search for alternate pain medications has gained more importance in the past few years due to nervous system related side‐effects with opioids, gastrointestinal dysfunction associated with non‐steroidal anti‐inflammatory drugs (NSAIDs), and cardiovascular anomalies with cyclo‐oxygenase‐2 inhibitors (COX‐2). Phytomedicine has been quite effective for treatment of pain, as these have been used for generations in regional communities, and tend to lack any major side‐effects. A dimer of cinnamic acid, Incarvillateine (INCA), derived from the Chinese herb Incarvillea sinensis, has its primary antinociceptive action through the adenosine receptor. Adenosine‐mediated analgesia has become an attractive target as it has the least side‐effects. We hypothesized that derivatives of cinnamic acid dimers, which structurally mimic INCA, show potent antinociceptive action, and their effect is mediated through adenosine receptor action. Compounds were synthesized using novel cavitand‐mediated photodimerization method, which utilizes a macromolecule (gamma‐cyclodextrin) to control the excited state reactivity of photoactive compounds to yield target tetra‐substituted cyclobutanes (dimers). The dimers generated so far show significant suppression of formalin‐induced acute pain in mice hind paw. Antinociceptive effect of ferulic acid dimer and 3‐methoxy cinnamic acid dimer was observed primarily in the inflammatory phase, and the dimer binds to the adenosine 3 receptors (as revealed by computer modeling). The pain suppressing response of these dimers was similar to that observed with indomethacin, an anti‐inflammatory drug. Even though morphine was more effective than the synthesized dimers in reducing neurogenic and inflammatory pain, there was no visible neurogenic side‐effects observed with administration of the dimers as commonly observed with morphine, which suggests a primary non‐opioid action. Our further characterization and selection of INCA analogs, with predominant adenosine receptor action, will help us to generate a new class of antinociceptives with precise chemical modifications using CMP methodology.Support or Funding InformationUNK Undergraduate Research Fellowship (AP, MH, WM, CC); Great Plains IDeA CTR Pilot Grant (MP, SC)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
The discovery of correlation observed among the cell elasticity and endocrine elasticity in breast cancer constitutes a revolution for knowledge and treatment of cancer 121 Copyright: ©2018 Lazo et al.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.