No abstract

The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR) = 2.03; p = 0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR = 1.12; p = 0.0005). Stratification analysis showed that this association was mainly driven by APOE ɛ4 noncarriers (OR = 1.14; p = 0.0025). MAPT H1 was also associated with risk for PD (OR = 1.30; p = 0.0003) and PSP (OR = 3.18; p = 8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE ɛ4 AD.

The WHO Collaborative Study on Psychol og ical Problems in General Health Care examined the frequency. form , course and outcome of psychological probl ems in general health c are senings. A total of 25.916 general heal th care anenders at 15 sites In 14 countries were scre en ed using the 12-item General Health Questionnaire (GHQ-12). Of those sc reened. 5,438 were asses sed in de tail using a Prim ary Health Care version of the Composite International Diagnostic Interview (CIDI-PHC) In conjunction with the Brief Disability Questionnaire. the Social Disability Schedules. a self rated overall health status fonn and the 28• nem General Health Que stionnaire. The analysis has shown that sleep problems were common at all sites with : 26 .8% of all pat ients ha ving some form of sleep problem and '5% of the patients examined had trouble failing or staying asleep.Ofthose with sleep problems. 51 .5% had a well-defined International Classification of Diseases 10th Revision (ICD-IO) mental disorder (such as depression. anxiety, sornatoform disorders or alcohol problems) and 48.5% of those with sleep problems for at least two weeks or more did not fulfil the criteria for any well defined ICD•I 0 diagnosis. Persons with sleep problems reported a degree of disability in the performance of their da ily activities and social roles even when they had no symptoms of psychological disorders. When such symptoms were present the disab ility was significantly increased. insomnia I general health care} ICD•I0 I Cross-cultural comparisons I sleep problems

Background This study explored the prevalence, socio-demographic characteristics and severity of different anxiety syndromes in five European primary care settings, as well as medical help-seeking, recognition by general practitioners (GPs) and treatment prescribed.Method The data were collected as part of the WHO study on Psychological Problems in General Health Care. Among 9714 consecutive primary care patients, 1973 were interviewed using the Composite International Diagnostic Interview. Reason for contact, ICD–10 diagnoses, severity and disability were assessed. Recognition rates and treatment prescribed were obtained from the GPs.Results Anxiety syndromes, whether corresponding to well-defined disorders or to subthreshold conditions, are frequent in primary care and are associated with a clinically significant degree of severity and substantial psychosocial disability. Their recognition by GPs as well as the proportion treated are low.Conclusions Since people with subthreshold anxiety show a substantial degree of disability and suffering, GPs may consider diagnostic criteria to be insufficient. However, their awareness of specific definitions and treatment patterns for anxiety disorders still needs a lot of improvement both for patients' well-being and for the cost resulting from non-treatment.