The diurnal pattern of plasma growth hormone levels has been investigated in nine children, without endocrinopathy, aged 8\p=n-\15 yr., from whom blood samples were taken hourly during the day and 2-hourly at night.Growth hormone was undetectable (< 1 \g=m\mg./ml.)during the first 2 hr. after meals but the levels rose thereafter to values many times higher than those found in adults. High values were consistently encountered during the night.
Since the isolation of growth hormone many of its actions on the total organism have been widely investigated and well recognized. The present report describes an attempt to locate the cells, within the cartilage of the upper tibial epiphysis, which respond to the stimulus of growth hormone. With the aid of tritiated thymidine (both in vitro and in vivo), colchicine and the electron micro-6. Trowell, C.
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