This chapter discusses why are the 3 unusual classes of lipid-binding proteins of nematodes (polyprotein antigens/allergens, fatty acid-binding proteins and fatty acid and retinol-binding proteins) interesting and describes their history and structures.
Antigenic, and hence possible evolutionary, relationships amongst various TPP‐dependent non‐oxidative α‐keto acid decarboxylases were determined by the Ouchterlony double diffusion method and by measuring the degree of antibody‐induced enzyme inhibition. The results show that: (a) phenylglyoxylate decarboxylases of various wild‐type strains of Acinetobacter calcoaceticus are antigenically indistinguishable; (b) there seems to be no antigenic cross‐reactivity between the phenylglyoxylate decarboxylase of A. calcoaceticus and of Pseudomonas aeruginosa or Pseudomonas putida; and (c) no antigenic homology can be detected amongst phenylglyoxylate decarboxylase and phenylpyruvate decarboxylase of A. calcoaceticus and pyruvate decarboxylase of brewers' yeast.
The Clinical Cancer Research Committee of the British Empire Cancer Campaign has registered I5,I97 cases of cancer seen in the hospitals of the Administrative County of London between April I, I938, and September 3, I939, of which I,063 or 7 per cent. were diagnosed as neoplasms of the bronchi, lungs, pleurae or mediastinum. The latest year for which the Registrar General's detailed figures are available is I937, from which we find for England and Wales 5 6 per cent. of all fatal cancer cases affected the lung. The London incidence is higher than that for the whole country, as will be explained later. Sex There were 87I males and I92 females, a ratio of 49 5 to i. This is in accordance with the findings of other observers, both in this country and abroad. Seyfarth (I924) gives the ratio as 5 .7 to I in 303 cases in Leipzig, Levy Simpson (i928) gives 4 to i for I39 cases in London, and at Brompton Hospital in Davidson's (I930) series the figures were 89 males to i8 females. This sex incidence is not confined to the lung, it is found also in cancer of the larynx and of the oesophagus. When the percentage incidence of cancer of the respiratory tract to that of all regions is examined in the two sexes, the difference is very striking. The table below shows the Registrar General's figures for I937 for (i) England and Wales, (2) the Administrative County of London, and (3) the British Empire Cancer Campaign's figures for the Administrative County of London for I7 months from April I, I938, to September 3, I939. Per cent. Per cent. of total of total Males cases Females cases England and Wales, I937, all sites a few of his figures.
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