Die Totalsynthese von Verbindungen niit Morphin-Struktur, wie sie zuerst von Crewel) beschritten wurde, fuhrte zu Substanzen, die denselben pharmakologischen Effekt zeigen wie das Morphin, vor alleni als Analgetikum. So zeigte das von Sc?mider und Gruus-neP) synthetisierte dl-3-Hydroxy-N-methyl-morphinan eine grol3e AktivitBt.HO-ft, HO-/\ I!
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