The effect of intraperitoneally applied 1.3-bis(piperidinomethyl)-5-ethyl-5-phenyl-barbituric acid on immune response in mice has been investigated. A marked depression of antihuman erythrocyte agglutinin titers was found following primary and secondary immunization; in the latter it mainly concerned 2-mercaptoethanol resistant antibodies. The immunological memory was influenced, too. The effects on humoral antibody reaction were dependent on dosage and timing. Chronic substance administration produced a lower progression of autoimmune nephropathy in (NMRI×NZB)F1 hybrid mice as evaluated by immunofluorescence photometry. However, the depression of circulating hemagglutinins did not coincide with a concomitant inhibition of cell-mediated immunity as examined by means of contact sensitivity and skin allografting in mice and phytohemagglutinin-stimulated human lymphocytes in vitro.
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