In photon beam convolution calculations where polyenergetic energy deposition kernels (EDKS) are used, the primary photon energy spectrum should be correctly accounted for in Monte Carlo generation of EDKS. This requires the probability of interaction, determined by the linear attenuation coefficient, mu, to be taken into account when primary photon interactions are forced to occur at the EDK origin. The use of primary and scattered EDKS generated with a fixed photon spectrum can give rise to an error in the dose calculation due to neglecting the effects of beam hardening with depth. The proportion of primary photon energy that is transferred to secondary electrons increases with depth of interaction, due to the increase in the ratio mu ab/mu as the beam hardens. Convolution depth-dose curves calculated using polyenergetic EDKS generated for the primary photon spectra which exist at depths of 0, 20 and 40 cm in water, show a fall-off which is too steep when compared with EGS4 Monte Carlo results. A beam hardening correction factor applied to primary and scattered 0 cm EDKS, based on the ratio of kerma to terma at each depth, gives primary, scattered and total dose in good agreement with Monte Carlo results.
Total and primary polyenergetic dose spread arrays (PDSA) have been generated for a high energy 10 MV radiotherapy photon beam using the electron gamma shower (EGS) Monte Carlo code. By considering the attenuation of fluence per energy interval, PDSA have been produced at radiological depths of 0 cm (the surface PDSA) and 40 cm (the beam hardened PDSA). By comparing primary PDSA produced at these different depths, the effect of beam hardening on the PDSA has been quantified. Calculations show that the mean electron range due to the surface primary PDSA is 6.67 mm and the mean electron range of the beam hardened primary PDSA is 8.24 mm. In comparison, a 3 MeV primary monoenergetic dose spread array (MDSA) has a much smaller mean electron range of 4.81 mm. A radiotherapy x-ray beam computation method is introduced which involves a single superposition of the surface generated PDSA or beam hardened PDSA with a polyenergetic TERMA. The mean percentage difference between depth-dose curves obtained using super-position of surface and beam hardened PDSA is only 0.1%. The mean percentage difference from experimental data for these superposition curves is 2.8% down to 40 cm in a homogeneous phantom. The superposition process is shown to be forgiving to spectral differences when calculating the PDSA, but sensitive to the incident photon energy spectrum used to calculate the TERMA.
Neuroendocrine tumours (NETs) belong to a relatively rare class of neoplasms. Nonetheless, their prevalence has increased significantly during the last decades. Peptide receptor radionuclide therapy (PRRT) is a relatively new treatment approach for inoperable or metastasised NETs. The therapeutic effect is based on the binding of radiolabelled somatostatin analogue peptides with NETs' somatostatin receptors, resulting in internal irradiation of tumours. Pre-therapeutic patient-specific dosimetry is essential to ensure that a treatment course has high levels of safety and efficacy. This paper reviews the methods applied for PRRT dosimetry, as well as the dosimetric results presented in the literature. Focus is given on data concerning the therapeutic somatostatin analogue radiopeptides (111)In-[DTPA(0),D-Phe(1)]-octreotide ((111)In-DTPA-octreotide), (90)Y-[DOTA(0),Tyr(3)]-octreotide ((90)Y-DOTATOC) and (177)Lu-[DOTA(0),Tyr(3),Thr(8)]-octreotide ((177)Lu-DOTATATE). Following the Medical Internal Radiation Dose (MIRD) Committee formalism, dosimetric analysis demonstrates large interpatient variability in tumour and organ uptake, with kidneys and bone marrow being the critical organs. The results are dependent on the image acquisition and processing protocol, as well as the dosimetric imaging radiopharmaceutical.
Abstract-A method for speed control of Brushed DC (BDC) motors is presented. It is particularly applicable to motors with armatures of less than one cubic centimetre. Motors with very small armatures are difficult to control using the usual PulseWidth Modulation (PWM) approach, and are apt to overheat if so driven. The technique regulates speed via the back EMF but does not require current-discontinuous drive. Armature heating in small motors under PWM drive is explained and quantified. The method is verified through simulation and measurement. Control is improved and armature losses are minimised. The method can expect to find application in miniature mechatronic equipment.
Continuing professional development (CPD) and continuing professional education (CPE) are seen as being necessary for medical physicists to ensure that they are up-to-date with current clinical practice. CPD is more than just continuing professional education, but can include research publication, working group contribution, thesis examination and many other activities. A systematic way of assessing and recording such activities that a medical physicist undertakes is used in a number of countries. This can be used for certification and licensing renewal purposes. Such systems are used in 27 countries, but they should be implemented in all countries where clinical medical physicists are employed. A survey of the CPD systems that are currently operated around the world is presented. In general they are quite similar although there are a few countries that have CPD systems that differ significantly from the others in many respects. Generally they ensure that medical physicists are kept up-to-date, although there are some that clearly will fail to achieve that. An analysis of what is required to construct a useful medical physics CPD system is made. Finally, the need for medical physicist professional organizations to cooperate and share in the production and distribution of CPD and CPE materials is emphasized.
A survey of the medical physics and biomedical engineering workforce was carried out in 2006. 495 positions (equivalent to 478 equivalent full time (EFT) positions) were captured by the survey. Of these 268 EFT were in radiation oncology physics, 36 EFT were in radiology physics, 44 were in nuclear medicine physics, 101 EFT were in biomedical engineering and 29 EFT were attributed to other activities. The survey reviewed the experience profile, the salary levels and the number of vacant positions in the workforce for the different disciplines in each Australian state and in New Zealand. Analysis of the data identifies staffing shortfalls in the various disciplines and demonstrates the difficulties that will occur in trying to train sufficient physicists to raise staffing to an acceptable level.
The contribution of radionuclide therapies (RNTs) to effective patient treatment is widely appreciated. The administration of high doses has necessitated investigating the potential radiation hazard to caregivers from patients undergoing RNTs. This work aimed to review the literature regarding measured effective doses to caregivers from such patients. The main selection criterion was the presence of real radiation exposure measurements. The results were categorised according to the treatment protocol and dose parameters. Analysis of the collected data demonstrated that the measured effective dose values were within the dose constraints defined by the International Commission on Radiological Protection, provided that the radiation protection instructions were followed by both patients and caregivers. In conclusion, the radiation risk for caregivers was almost negligible. In this context, treatments could be administered more often on an outpatient basis, once cost-effectiveness criteria were established and radiation protection training and procedures were appropriately applied.
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