Investigation of the Pulmonary Circulation by means of a Double-Isotope TechniqueSummary. Following simultaneous injection of RISA-J-131 (MW 69000) and Antipyrin-J-125 (MW 326) into the jugular vein, the time-concentration curves of the 2 isotopes were measured after cardiopulmonary passage. Due to its low molecular weight, the antipyrine penetrates into the extravascular space. Therefore the difference between the volume of albumin and that of antipyrine can be regarded as an indicator of the development of interstitial pulmonary edema. A significant increase in the extravascular volume was also seen in experimental myocardial infarction up to 5hrs after ligature of the coronary artery. Experimental fracture of the femur was performed in rabbits: 90 min later an increase of the extravascular volume by 0.5 ml/kg body weight was determined. Key words: Double-isotope technique -Extravascular volume -Interstitial pulmonary edemaZusammenfassung. Nach der gleichzeitigen Injektion von RISA-J-131 (MG 69000) und Antipyrin-J-125 (MG 326) in die Vena jugularis werden die Zeitkonzentrationskurven der Isotopen nach der Herz-Lungen-Passage gemessen. Das kleinmolekulare Antipyrin verteilt sich w~ihrend der Passage auch aul3erhalb der Gef~il3e. Die Subtraktion des Albuminraumes von dem Antipyrinraum erm6glicht es deshalb, die Entstehung eines interstitiellen Lungen6dems quantitativ zu messen. Beim experimentellen Herzinfarkt konnte eine signifikante Zunahme des extravascul~iren Volumens bis zu 5 Std nach dem Infarkt gemessen werden. In Versuchen an Kaninchen mit experimenteller Oberschenkelfraktur erkennt man nach 90 min eine Vergr613erung des extravascul~iren Volumens um 0,5 mg/kg KG.Schliisselwfrter: Doppelisotopentechnik -extravascul~ires Volumen -interstitielles Lungen6dem
Mfmchen Methods for Measuring Reparative Processes in Skin Wounds~ummary. Standardized punch-hole wounds were produced on the dorsal skin of rats to measure wound-healing processes. Two methods were used:1. Photographic Method. The original wound area is compared to the wound areas on days 3, 6, and 9 and the differences are statistically evaluated. This model allows the study of the effect of Kallikrein on the healing process.2. Thermographic Method. Isothermic regions are measured in three circular zones of the wound. The most peripheral zone equals 0; the f~t~l wound temperature on days 3, 6, and 8 is compared to this value and the results are subjected to statistical analysis. ~chl~sselw6rter: Wundheilung --Wundfli~chenvermessung --Thermographie --Kallikrein®. Die Malabsorption als chirurgische Therapie der extremen Fettsucht B. Husemann Erlangen Malabsorption as a Surgical Therapy for Extreme Obesity~umntary. Because of the poor effect of internal therapy of extreme obesity, the jejunoileal bypass is being used with increasing frequency. The malabsorption brings about a good weight loss and normalizes the fat and carbohydrate intolerance. Complications are rare under medical supervision. Age over 50 years and absence of cooperation contraindicate this operation. The long-term effect is dependent on the patient himself; he must learn to reduce his calorie intake and to adopt new habits.Key wards: Obesity --Jejuno-Ileal Shunt --Malabsorption.Zusammeniassung. Wegen des geringen Dauererfolgs der konservativen Therapie der extremen Fettsucht wird die sog. Dfinndarmausschaltungseperation in Form der Jejunoileostomie mit 20 em Jejunum und 20 em unterem Ileum hi~ufiger angewandt. Die Malabsorption ffihrt zur Gewichtsabnahme, Fetthaushalt und Kohlenhydratinteleranz normalisieren sich. Komplikationen sind selten. Als Kontraintlilcationen gelten ein Alter fiber 50 Jahren und eine mangelnde Bereitschaft zur Kooperation. Der Langzeiterfolg hi~ngt entseheidend vom Patienten selbst ab: Er mull lernen, eine vernfinftige Lebensweise zu fiihren.Bcld~seIwfrter: Fettsucht, Dfinndarmausechaltung --Malabsorption.
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