A double-blind crossover comparison of three different single doses of a selective serotonin reuptake inhibitor, zimelidine, and a placebo on quantified EEG parameters and psychological variables was carried out in ten healthy male volunteers. Each subject randomly received 100 mg, 200 rng and 300 mg of zimelidine as well as placebo. C,-P,, P, +, G P , ,Prol and F r o , EEG samples were taken by means of collodium Ag/ AgCl stick on electrodes. 3 min average Fast Fourier Transformation power spectra based on 5 sec epochs were established. Additionally, performance tests and a subjective self-rating were carried out. The measurements, performed according to a strictly controlled schedule, were repeated 1,2,4 and 6 h post baseline (i.e. 8 a.m.). The data analysis was performed by means of two-way variance analysis for repeated measurements.Administration of three different single oral doses of zimelidine was found to significantly stabilize the average vigilance behaviour in terms of reduced slow wave EEG activity and of increased monorhythmic alpha activity. Simultaneously, concentration ability was improved and mild feelings of activation were reported. The results are discussed in the light of biochemical aspects and with regard to neurophysiological vigilance concepts.The pharmacoelectroencephalographic classificational approach is, up to now, based on a rather operational model of drug efficacy in normals and patients, respectively (e.g. Fink [ , 19691, Ztil [1968). The most important presumption is that psychotropic drug effects are due to neurobiochemical actions which are qualitatively identical in both healthy and mentally diseased persons. According to this working model, biochemical CNS changes during the course of psychiatric disturbances primarily reflect quantitative deviations, i.e. disturbances in the normal ratios or relationships of the brain's biochemical entities. This can best be understood in terms of an imbalance of the normal coordination or homoeostasis of the entire biochemical CNS system.From the pharmacoelectroencephalographic experience much evidence appears in support of this model. Classically, the major types of psychotropic drugs were tested (mostly in normals) to establish typical profiles of the electroencephalographic (EEG)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.