[9188][9189][9190][9191][9192], the authors request that the following be noted. The last paragraph on p. 9188 should read: "Others have obtained experimental evidence indicating that the region of IL-2 that contains peptide IL2-A is important for activity. Ju et al. (25) used site-directed mutagenesis to determine that residues 21-40 of IL-2 (residues 1-20 of the mature protein) form one of the regions of IL-2 required for full biological activity and that this region is recognized by neutralizing anti-IL-2 antibodies. Chizzonite et al. (24) Communicated by William A. Goddard III, August 8, 1986 ABSTRACT A region of homology has been found between the envelope (env) protein of the acquired immunodeficiency syndrome (AIDS) virus and a portion of interleukin 2 (IL-2) that purportedly binds to the IL-2 receptor. This homology, between two proteins associated with opposing biological functions, suggests possible mechanisms for the immunosuppressive activity of the AIDS virus. Two mechanisms are proposed in which the AIDS virus env protein interferes with IL-2 activity either directly or indirectly. A region of similarity to the purported IL-2 receptor binding site on IL-2 and AIDS virus env is present in the env proteins of other retroviruses associated with immunosuppression. A synthetic peptide vaccine for AIDS is suggested based on the IL-2 receptor binding sequence in AIDS virus env.
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