36 tall girls aged 10.3 to 15.5 years were treated with ethinylestradiol (0.5 mg/day) and norethisterone (15 mg/day). To date treatment for seventeen girls has been completed. Before treatment their bone age ranged from 11.0 to 13.5 years and mean height prediction was 185.19 cm (181.40-193.00 cm). After about two years of treatment their final height averaged 178.96 cm (171.60-183.50 cm). Predicted height was reduced by an average of 6.23 cm. The reduction in final height was significantly greater when therapy was started before a bone age of 12 years. Thirteen girls, re-examined after discontinuation of therapy, all had regular menstrual bleeding within six months. There were no serious or irreversible side effects during the period of observation.
Dysmorphology reportsWhen reviewed at five months of age he had failed to grow satisfactorily. His weight was 3-5 kg (1-5 kg<3rd centile), length 58 cm (3rd centile), and OFC 37-8 cm (2 cm<3rd centile).The following features were noted on examination: prominent epicanthic folds, long philtrum, high palate, micrognathia, a narrow upper lip, and low set, posteriorly rotated ears. He was having intermittent upper airway obstruction. A choanogram showed bilateral choanal hypoplasia with stenosis and he required a tracheostomy to prevent further episodes of upper airways occlusion.At review at two years he was still of short stature. His
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.