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THE COMPLICATIONS of primary tumors of the small intestine usually considered to be of surgical significance are related to their growth and metastasis. These include intestinal obstruction, intussusception, hemorrhage, and perforation. In addition, other complications may develop from the effects of metabolic products of certain tumors, particularly the carcinoids.Recently another interesting characteristic of small bowel tumors has been noted, their association with an increased incidence of concurrent neoplasms in other parts of the body. To study this association, a review of all of the autopsy material at the Cincinnati General Hospital over a 15 year period has been made. This incidence of concurrent neoplastic growths was studied in patients with primary neoplasms of the small intestine and compared with that found in patients in the general autopsy population with allowances being made for age. The results of this study indicate that individuals with primary neoplasms of the small intestine are particularly prone to develop primary neoplasms elsewhere.

Employing a sensitive and immunoglobulin-specific assay method based upon antiglobulin augmentation, quantitative and qualitative aspects of the primary and secondary response of the rabbit to Salmonella typhimurium O antigens have been evaluated. These studies examine the validity of the method of assay for detecting and measuring γG- and γM-antibodies produced in response to whole organisms or its lipopolysaccharide. The results show that during the primary response γG-antibodies, not detectable by usual techniques, are produced in a pattern similar to that reported in animals stimulated by other classes of antigens. Moreover, the γG response following reinjection is characteristic of a secondary-type response. In contrast, γM-antibody levels after both primary and secondary stimulation rose equally to levels between 1 and 4 mg/ml. Despite increased sensitivity of detection and quantitative estimates of the actual molar concentration of each immunoglobulin, the minimal interval between γM and γG appearance in serum was not less than 1.5 days. The variable degree of augmentation of agglutination by antiglobulin reagent found during the immune response severely limits the quantitative usefulness of the methods developed. However, the data suggest that qualitative changes in anti-O antibodies interpretable as changes in avidity occur regularly during the immune response.