A series of 14 new (−)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC 50 values of 20.93, 13.58, and 9.40 M, respectively. However, in an antibacterial test, compounds a and b inhibited Staphylococcus aureus and Bacillus cereus and compound e inhibited only Staphylococcus aureus at the same MIC values of 1024 g/ml.
The recent statistical data have revealed that cancerdiseases characterized by uncontrolled cell growth, metastasis and invasion are responsible for approximate 13 % of all human deaths throughout the world 1 . Three most fatal cancers are lung, liver and breast cancer. It is documented that in many cellular processes, including cell proliferation, metabolism, survival and apoptosis, there are involvements of protein tyrosine kinase enzymes. The tumor growth and progression are known to be driven by several protein tyrosine kinases, which are activated in cancer cells 2 . The uncontrolled cell growth is known to result from over expression, constitutive activation or mutation caused by inappropriate or uncontrolled activation of these kinases 3 .Quinoline, a heterocyclic aromatic compound, is considered to be an important scaffold and prevalent in variety of pharmacologically active synthetic compounds as well as in naturally occurring products 4 . Studies have shown that quinoline derivatives possess a wide range of biological activities, including antimalarial 5 , antibacterial 6 , antitumor 7,8 , anticancer 9 , antidepressant activities 10 . Recent continued researches about cytotoxic activities of quinoline derivatives have resulted in a lot of encouraging results 11 .Among different structural classes of tyrosine kinase inhibitions, 4-anilino-quinazoline and its bio-isosteric, 4-anilinoquinolines have been reported to be the most promising molecules, which were selective inhibition to epidermal cell growth factor receptor (EGFR) 12 . Some recently synthesized anilinoquinoline derivatives exhibited potent inhibitory activity against MCF-7 cell line 13 .
: In this work, molybdenum disulfide (MoS2) nanorods (NRs) were prepared by a simple hydrothermal method. A sensitive electrochemical glucose biosensor was developed based on the immobilization of glucose oxidase (GOx) on MoS2 NRs modified glassy carbon electrode (GCE). The SnO2 NRs were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS). SnO2 NRs have large specific area and can load large amounts of GOx molecules. The cyclic voltammetry (CV) of GOx/MoS2 NR/GCE exhibited a linear relationship between the peak current density of CV with glucose concentration in the range of 3.0 mM to 7.0 mM with the limit of detection (LOD) of 3.0 mM and high sensitivity of mA.mM. The parameters affecting the oxidation current density such as pH, temperature, GOx concentration were also investigated. This study demonstrates the feasibility of realizing inexpensive, reliable, and highly effective performance glucose biosensors using MoS2 nanorods.
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