Optimal conditions for the assessment of T cell proliferation and cytolytic T lymphocyte (CTL) responses specific for primate lentivirus were established. CTL and T cell proliferative responses were demonstrated as early as two weeks post‐infection. Although the majority of CTL were CD8+, MHC class I‐restricted, this study demonstrated CD4+, MHC class II‐restricted CTL. Experiments also demonstrated that CTL were CD 16 negative. Target cell generation could be blocked with CD4 mAb specific for the SIV binding site.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.