The aim: To evaluate the levels of plasminogen activator type 1 inhibitor, asymmetric dimethylarginine and endothelial nitric oxide synthase on day 10-14 in patients, depending on the presence or absence of concomitant type 2 diabetes and the type of reperfusion therapy.
Materials and methods: The study involved 130 patients with acute myocardial infarction, divided into 2 groups: Group 1 consisted of patients with acute myocardial infarction with type 2 diabetes mellitus (n = 73), Group 2 comprised patients with acute type 2 diabetes mellitus (n = 57). The quantitative content of IAP-1 was determined by enzymelinked immunosorbent assay using a commercial test system manufactured by Technoclone PAI-1 ELISA Kit (Austria), NOS – Enzyme-Linked Immunosorbent Assay (ELISA) Kit for Nitric Oxide Synthase Endothelial (NOS) ADMA ELISA Kit (Austria).
Results and conclusions: Percutaneous coronary intervention contributes to a significant reduction in the content of ADMA, which is a marker of endothelial dysfunction and increase NOS on the 10-14th day of acute myocardial infarction compared with standard therapy. During PCI, the level of IAP-1 did not significantly change in the time course of treatment due to post-inflammatory and post-traumatic activation of platelets in the vascular wall.
The study showed that for patients with anemia, developed on a background of chronic heartfailure (CHF) and diabetic nephropathy is characterized more severe disorders of iron metabolism(decrease transferrin, erythropoietin and soluble transferrin receptor / log ferritin index) in comparedwith patients with CHF and chronic pyelonephritis. In assessing of the differences degree between ane-mic patients with CHF, depending on the availability of diabetic nephropathy or chronic pyelonephritisthe most difference was detected in the levels of erythropoietin
It was examined 15 patients with acute myocardial infarction and were divided on groups depending on the presence or absence of concomitant diabetes mellitus type 2 and selected tactics of treatment (fibrinolytic or standart antiplatelet therapy). It was estimated requency of the complications development in acute period of myocardial infarction. It was found that patients with concomitant diabetes mellitus the most frequently had complicated course of acute phase of myocardial infarction in comparison with patients without previous fibrinolytic therapy. Using of fibrinolytic therapy has leveled the negative influence of diabetes mellitus on short-term prognosis of these patients. It’s confirmed the necessity of its carrying out in patients with co morbid pathology.
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