This study demonstrates that nonfluoroscopic electrophysiologic studies and right-sided catheter ablations for supraventricular tachycardia can be safely and effectively performed in the majority of patients with normal cardiac anatomy using NavX. Further studies will be necessary in order to establish the potential utility of NavX in eliminating or decreasing radiation exposure for other electrophysiology procedures.

Patients with nonpost-operative JET have a wide range of clinical presentations, with younger patients demonstrating higher morbidity and mortality. With current medical, ablative, and device therapies, the majority of patients have a good clinical outcome.

The heart rate complexity is reduced with a significant decreasing trend as assessed by R-R interval entropy prior to the onset of AF. There is a need for well-defined studies with larger patient groups in order to assess the entropy changes further and to look for possible changes, which might predict impending AF episodes.

Background— Transgenic and gene-targeted models have focused on the mouse. Fundamental differences between the mouse and human exist in Ca 2+ handling during contraction/relaxation and in alterations in Ca 2+ flux during heart failure, with the rabbit more accurately reflecting the human system. Methods and Results— Cardiac troponin I (cTnI) mutations can cause familial hypertrophic cardiomyopathy. An inhibitory domain mutation, arginine146→glycine (cTnI 146Gly ), was modeled with the use of transgenic expression in the rabbit ventricle. cTnI 146Gly levels >40% of total cTnI were perinatally lethal, whereas replacement levels of 15% to 25% were well tolerated. cTnI 146Gly expression led to a leftward shift in the force-pCa 2+ curves with cardiomyocyte disarray, fibrosis, and altered connexin43 organization. In isolated cTnI 146Gly myocytes, twitch relaxation amplitudes were smaller than in normal cells, but [Ca] i transients and sarcoplasmic reticulum Ca 2+ load were not different. Detrended fluctuation analysis of the QT max intervals was used to evaluate the cardiac repolarization phase and showed a significantly higher scaling exponent in the transgenic animals. Conclusions— Expression of modest amounts of cTnI 146Gly led to subtle defects without severely affecting cardiac function. Aberrant connexin organization, subtle morphological deficits, and an altered fractal pattern of the repolarization phase of transgenic rabbits, in the absence of entropy or other ECG abnormalities, may indicate an early developing pathology before the onset of more obvious repolarization abnormalities or major alterations in cardiac mechanics.

The trial is registered at www.ClinicalTrials.gov, NCT00556361.

Fluoroscopy can be significantly decreased or even eliminated in the majority of catheter ablation procedures. Long-term results demonstrate that this can be done efficiently and safely.

Cryoablation of APs is safe and yields to high acute success rates in children. It can potentially be used as the first ablation option for all APs in children. However, recurrence rate is higher compared to the RFA and there is a need for prospective comparative studies.

Abstract