Novel benzylideneimines, iminomethyl‐phenoles and iminoethyl‐benzopyran‐ 2‐ones were synthesized by condensation reactions of benzaldehyde analogues and acetyl‐benzopyran‐2‐one and heterocyclic amines. Condensation of 3‐acetylbenzopyran‐2‐one 1a and 2‐aminopyridines and 2‐aminopyrimidine 2(a‐c) resulted by synthesis of corresponding derivates of [2‐ylimino)‐ethyl]‐benzopyran‐2‐one 3(a‐c). By catalytic condensation of benzaldehyde and their analogues 1(b‐d) and 2‐amino‐5‐bromothiazole, 2‐aminobenzothiazoles and 2‐aminopyrimidines 2(d‐h), novel benzylideneimine derivatives 3(d‐h) were syntesized. The antibacterial activity of products 3(a‐h) against S. aureus, E. coli dhe Clebsiella were investigated and reported. Results of inhibition zones were indicated for considerable activity of these compounds against these microorganisms. Compounds 3f and 3c were more active against Staphylococcus aureus. Compounds 3c and 3g exhibited the strongest activity against Clebsiella, whereas 3d was more active against Escherichia coli. In general there was a driect positive correlation between increasing concentration of the compound and anitbacterial activity.
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