Iako su parodontitis i periimplantitis uzročno povezani s takozvanim parodontopatogenim bakterijama, rezultati nedavno objavljenog sistematiziranog preglednog rada i metaanaliza dali su visokokvalitetne dokaze da obrazac bolesti određuju uglavnom kvantitativne karakteristike oralnoga mikrobioma, a ne samo određeni patogen (1, 2, 3, 4). Čini se da je mikrobiom kvalitativno razmjerno sličan u zdravom i bolesnom parodontu ili oko implantata, ali su uočene promje-ACTA STOMATOLOGICA CROATICA
Chlamydia pneumoniae is an obligate intracellular bacterium that causes respiratory infection in adults and children. There may exist an association between atypical bacterial pathogens (C. pneumoniae, Mycoplasma pneumoniae) and asthma, as well as production of immunoglobulin (Ig) E responses in vitro. Previous studies in our laboratory demonstrated that doxycycline suppresses C. pneumoniae-induced production of IgE in peripheral blood mononuclear cells (PBMC) from IgE+ allergic asthmatic subjects. Whereas macrolides have anti-chlamydial activity, their effect on anti-inflammatory (IgE) responses to C. pneumoniae has not been studied. METHODS: Total serum IgE levels were assayed (ELISA). PBMC (1.5 x 10 6) from IgE negative adult atopic subjects (N55) were infected +/-C. pneumoniae BAL69 (multiplicity of infection of 0.1), +/-azithromycin (0.1, 1.0 ug/mL) for 10 days. IgE levels were determined in supernatants by ELISA. A single unequivocally positive skin test, or history of atopic dermatitis or allergic rhinitis defined atopy. RESULTS: Total serum IgE levels were low in all subjects (<100 IU/mL). IgE was detected in supernatants of PBMC on day 10. When azithromycin (0.1 ug/ml) was added to cultures, IgE levels increased (50%), but when azithromycin (1.0 ug/mL) was added IgE levels decreased (38%). When PBMC were infected with C. pneumoniae, IgE levels decreased (63%). Addition of azithromycin (0.1, 1.0 ug/mL) had no effect on IgE levels (0-3%). CONCLUSIONS: These findings indicate that azithromycin had a bimodal affect on IgE responses in PBMC from atopic patients in vitro and may have immunomodulatory properties. However, azithromycin doesn't modulate C. pneumoniae-induced production of IgE.
Коронний розряд знайшов своє застосування в різних галузях науки і техніки. Коронний розряд, що протікає при високих частотах, застосовується для поверхневого легування металів і напівпровідників, для очищення газів від пилу в складі електростатичних фільтрів, для діагностики станів конструкцій. У статті наводяться результати дослідження з управління розрядом за допомогою амплітудної модуляції.
At the issue represented the etiopathogenesis of the chronic fatigue syndrome of (CFS) with immune dysfunction. Many doctors consider this problem only from the point of view of non-psychological disorders requiring only psycho-correction and non-drug treatment. However, syndromocomplex of CFS includes not only neuropsychiatric disorders, but also fibromyalgia syndrome, unexplained genesis, lymphadenopathy, non-specific polyarthralgias. It is also controversial about the feasibility of treating type 6 herpesviruses and type 7 viruses. Some authors consider the need for antiviral therapy only when reactivating the herpesvirus infection, in the transplantation of organs and tissues. However, for frequent HHV-7 and HHV-6 viremia remains resistant to ganciclovir, unlike CMV and EBV, which is successfully controlled by viremia.
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