Using the artificial beta-cell (Biostator), we determined the insulin requirements in five nonobese type I (insulin-dependent) diabetic subjects who received isocaloric 40 and 60% mixed-carbohydrate diets in a crossover randomized fashion for 4 days, each day consisting of four equal meals. This was followed on day 5 by a "Big Mac Attack" lunch consisting of a Big Mac, french fries, and milk shake. Insulin requirements to maintain normoglycemia were calculated for each 24-h period and for the 2 h after each meal. The mean 24-h insulin requirements to maintain normoglycemia was greater for the 60% carbohydrate diet than the 40% diet. Although the four meals were of equal size, in all patients the insulin required to cover breakfast greater than lunch greater than dinner greater than or equal to snack. Expressed as milliunits per kilocalorie, the amount of insulin to cover breakfast was greater for the 60% (P less than .05) than the 40% carbohydrate diet and greater for breakfast than the other meals (P less than .01). Insulin requirements for the Big Mac (43% carbohydrate) were 58% greater than for the 40% carbohydrate diet, even after correction for caloric differences. In summary, 1) increasing dietary carbohydrate from 40 to 60% results in an increased insulin requirement for meals only; 2) insulin requirements are greater in the morning than in the evening, even when meal size is constant; and 3) very large meals with high fat and carbohydrate content result in a major increase in insulin requirement. These data indicate that diet has an important impact on insulin requirements in diabetes.
The artificial beta-cell can establish normoglycemia within 2 h in an indifferently controlled diabetic patient. In the present study, the temporal relationship between the achievement of normoglycemia and its effect on plasma lipid concentrations has been examined in 12 insulin-dependent diabetic patients regulated by the artificial beta-cell for 7 days. The fasting values (mean +/- SEM) of blood glucose (BG), triglycerides (TG), total cholesterol (T-chol), HDL-cholesterol (HDL), and the calculated LDL/HDL ratio (obtained while participants were on single or split insulin regimens) were 385 +/- 42 mg/dl, 148 +/- 24 mg/dl, 219 +/- 22 mg/dl, 39 +/- 3.6 mg/dl, and 3.8 +/- 1.04, respectively. Within 12 h of establishing normoglycemia TG levels fell to 87 +/- 10 mg/dl (P less than 0.001), T-chol to 196 +/- 15 mg/dl (P less than 0.005), and HDL to 37 +/- 3 mg/dl (P = NS). The LDL/HDL ratio remained unchanged. After 7 days on the artificial beta-cell, the corresponding values were: 73 +/- 5 mg/dl (P less than 0.001), 169 +/- 9 mg/dl (P less than 0.001), 41 +/- 2.6 mg/dl (P = NS), and 2.6 +/- 0.56 (P less than 0.05). Twenty-four hours after discontinuation of artificial beta-cell therapy, the TG and T-chol concentrations reverted to baseline. These findings underscore the rapidity and effectiveness with which strict control can improve plasma lipid profiles.
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