METHs are drugs that enter wastewater through the feces and urine of users. Conventional wastewater treatment plants are not capable of removing this type of emerging contaminant, but, in recent years, techniques have been developed to abate drugs of abuse. The present investigation focused on obtaining the technique that keeps the best balance between the comparison criteria considered: efficiency; costs; development stage; and waste generation. That is why a bibliographic review was carried out in the scientific databases of the last eight years, concluding that the six most popular techniques are: SBR, Fenton reaction, mixed-flow bioreactor, ozonation, photocatalysis, and UV disinfection. Subsequently, the Saaty and Modified Saaty methods were applied, obtaining a polynomial equation containing the four comparison criteria for the evaluation of the techniques. It is concluded that the UV disinfection method is the one with the best relationship between the analyzed criteria, reaching a score of 0.8591/1, followed by the Fenton method with a score of 0.6925/1. This research work constitutes a practical and easy-to-use tool for decision-makers, since it allows finding an optimal treatment for the abatement of METHs.