Cherenkov
radiation (CR), the blue light seen in nuclear reactors,
is emitted by some radiopharmaceuticals. This study showed that (1)
a portion of CR could be transferred in the region of the optical
spectrum, where biological tissues are most transparent: as a result,
upon radiance amplification in the near-infrared window, the detection
of light could occur twice deeper in tissues than during classical
Cherenkov luminescence imaging and (2) Cherenkov-photodynamic therapy
(CR-PDT) on cells could be achieved under conditions mimicking unlimited
depth using the CR-embarked light source, which is unlike standard
PDT, where light penetration depth is limited in biological tissues.
Both results are of utmost importance for simultaneous applications
in tumor resection and post-resection treatment of remaining unresected
margins, thanks to a molecular construct designed to raise its light
collection efficiency (i.e., CR energy transfer)
by conjugation with multiple CR-absorbing (water-soluble) antenna
followed by intramolecular-FRET/TBET energy transfers.
International audienceSubphthalocyanine (SubPc) could be reversibly protonated at the azomethine bridge. This phenomenon was examined by addressing the pKa of the acid (TFA, MSA, TMSA) and the SubPc electron-withdrawing properties of the peripheral isoindolic substituents (F12 vs. H12 and NO2), which tunes the basic character of the azomethine moiety. The protonation of up to three azomethines was suggested and monitored spectrophotometrically with the appearance of new absorption bands at 610, 630 nm and 660 nm, together with marked colour changes from purple to blue to green. Evidence of such a protonation was also shown by significant changes in the 1H-NMR spectrum and new bands in the infrared spectrum
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