Intracranial meningiomas continue to challenge our best clinical efforts to eliminate them once discovered and deemed appropriate for treatment. Malignant meningiomas constitute 10% to 15% of all meningiomas and limited information exists regarding adjuvant treatment. The external whole brain irradiation is recommended. Traditional chemotherapy has proven ineffective; thus, new chemotherapeutic agents and new methods of delivery should be developed. Immunotherapy may be considered for patients with malignant meningiomas when all others previous treatment have failed. We report a rare case of Psammomatous anaplastic meningioma. A 45-year-old man presented with head ache since 15 days and vomiting since 13days. Magnetic resonance image demonstrated a large left frontal mass with heterogenous enhancement and moderate peri-lesional edema. The tumor and the infiltrated dura were radically removed. Postoperatively, the patient remained neurologically intact.
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