Resumo Objetivo Verificar a associação entre os marcadores de fragilidade e as características sociodemográficas e clínicas em idosos na Atenção Primária à Saúde. Método Pesquisa transversal, realizada com 356 idosos cadastrados em unidades de saúde da família, no Nordeste do Brasil. Os instrumentos de coleta utilizados foram o Índice de Vulnerabilidade Clínico-Funcional e outro de perfil socioeconômico e de saúde. Analisaram-se os dados pela estatística inferencial, utilizando o teste do Qui-quadrado, com nível de significância 0,05. Resultados A média de idade foi de 72,85 anos (±8,965); 63,8% eram do sexo feminino, 39% apresentaram risco de fragilização e 22,5% demonstraram fragilidade. Houve associação entre fragilidade, sexo, faixa etária, estado civil, escolaridade, renda, presença de doença cardíaca e hipertensão. Conclusões e implicações para a prática Os marcadores de fragilidade nos idosos evidenciaram associação entre as características sociodemográficas e clínicas, indicando a necessidade de rastreio precoce no nível primário de atenção à saúde.

The pathogenic yeast Candida glabrata is intrinsically resilient to azoles and rapidly acquires resistance to these antifungals, in vitro and in vivo. In most cases azole-resistant C. glabrata clinical strains encode hyperactive CgPdr1 variants, however, resistant strains encoding wild-type CgPDR1 alleles have also been isolated, although remaining to be disclosed the underlying resistance mechanism. In this work we scrutinized the mechanisms underlying resistance to azoles of eight resistant clinical C. glabrata strains, identified along the course of epidemiological surveys undertaken in Portugal. Seven of the strains were found to encode CgPdr1 GOF variants (I392M, E555K, G558C and I803T) with the substitutions I392M and I803T being herein identified as hyper-activating mutations for the first time. While cells expressing the wild-type CgPDR1 allele required the mediator subunit Gal11A to enhance tolerance to fluconazole, this was dispensable for cells expressing the I803T variant clearly indicating that the CgPdr1 interactome is shaped by different GOF substitutions. Genomic and transcriptomic profiling of the sole azole-resistant C. glabrata isolate encoding a wild-type CgPDR1 allele (ISTB218) revealed that under fluconazole stress this strain over-expresses various genes described to provide protection against this antifungal, while also showing reduced expression of genes described to increase sensitivity to these drugs. The overall role in driving the azole-resistance phenotype of the ISTB218 C. glabrata isolate played by these changes in the transcriptome and genome of the ISTB218 isolate are discussed shedding light into mechanisms of resistance that go beyond the CgPdr1-signalling pathway and that may alone, or in combination, pave the way for the acquisition of resistance to azoles in vivo.

It is relevant to highlight the importance of nurses in patient care in renal replacement therapy, which has an important care function, health education and psychological support. At this juncture, for nursing care to be optimized, it must occur systematically, through the application of the Nursing Process, which is organized into five stages: history, diagnoses, planning, implementation and evaluation of nursing. Thus, the objective of the present study was to report the experience of nursing undergraduates during the application of the Nursing Process to a patient on hemodialysis therapy. From the analysis of the information obtained from the patient's history, nursing evolution and general physical examination, five guiding parameters were established to support the use of the North American Nursing Diagnosis Association classifications: Risk of Vascular Trauma, Risk of Infection, Constipation, Knowledge and Confrontation, and from these were elaborated the diagnoses, interventions and results for each finding. There was a need to maintain aseptic means to prevent infection. Constipation was due to water restriction required during therapy. Knowledge was insufficient about their own health condition, and despite the limitations of treatment it was resilient during coping. The reported experience was of great value to know how care is provided to patients with chronic kidney disease, inserting the Nursing Process as a working tool of nurses in clinical daily life, and the use of taxonomies was important to standardize language. and nursing actions.

O acidente Vascular Cerebral é apontado como uma das doenças mais incapacitante, pois cerca de 70% das pessoas que são acometidas pela patologia não conseguem retomar as suas atividades diárias e aproximadamente 50% dos indivíduos ficam dependentes de outras pessoas. O estudo objetivou-se em analisar e descrever quais as principais intervenções de enfermagem ao paciente acometido por AVC. O estudo trata-se de uma revisão integrativa onde a busca dos artigos ocorreu no mês de agosto de 2018, foram utilizados os descritores acidente vascular cerebral, assistência ao paciente e enfermagem, cruzados com o operador booleano AND, nas bibliotecas virtuais BVS e SciELO, na PUBMED foram utilizados os descritores cadastrados no Medical Subject Headings (MesH): “Stroke” AND “Patient Care” AND “Nursing”. As buscas resultaram num total de 3723 em todas as bases de dados, onde após os critérios de inclusão e exclusão foram selecionados 09 artigos para compor o estudo. As intervenções da equipe de Enfermagem devem ser direcionadas aos cuidados assistenciais ao paciente envolvendo ações que variam desde uma avaliação do indivíduo, como a realização de atividades direcionadas ao treinamento da fala, marcha, avaliação do hábito miccional, avaliação da higiene oral e assistência direcionada ao posicionamento correto do paciente, além da avaliação dos riscos de quedas e prevenção de um novo AVC. Diante disso, é necessário que o enfermeiro esteja apto a desenvolver um plano de cuidados voltado para a reabilitação do paciente, sendo necessária a integração de uma equipe multidisciplinar, promovendo assim, um cuidado humanizado e integral.

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Paspalum notatum is an important forage native to Southern Brazil and one of the most promising fodder species in terms of productivity, quality, resistance and growth speed. The objective of this study was to evaluate the reproductive mode and fertility of hybrid progenies resulting from artificial crosses among artificially duplicated sexual plants, selected intraspecific hybrids of the UFRGS breeding program and apomictic ecotypes of the species. The resulting F 1 progenies were represented by 24 plants with high pollen viability (varying from 82.15 to 99.67%) and 1.2:1 segregation for the sexual: apomictic reproduction mode, indicating predominantly sexual hybrids, due to distorted segregation. In the apomictic plants, most chromosomes paired as bivalents in diakinesis. Since the low presence of abnormalities observed in the meiotic chromosome pairing and the high pollen viability of the hybrids, all plants were confirmed as promising parents for future crosses.

Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

Objective identify in the literature how care-educational gerontechnologies have been constructed and validated and recommended propositions for their development. Method integrative literature review carried out in the Web of Science, LILACS, CINAHL, BDENF, MEDLINE and SciELO databases following the recommendation of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We selected studies that presented the construction and validation of gerontechnologies. For data extraction, we used an instrument adapted from the international RedENSO. We also classified the level of evidence of the studies according to Melnyk and Fineout-Overholt Results We analyzed 17 studies. The year 2019 had the highest number of publications on the subject, with the majority coming from Brazil. The development of material gerontechnologies, as booklets, leaflets, manuals, games, software and multimedia materials, was more reported. Regarding the method of construction of gerontechnologies adopted in the studies, situational diagnosis through interviews, dialogues and scales, and literature reviews on the themes stood out. In most studies, validation was performed with the elderlies and, in some studies, validation was also performed with specialists. Conclusion We found that the process of development of care-educational gerontechnologies is recent and requires improvement in the validation stage and not always performed by researchers. Regarding the recommendations for their development, we highlight the use of language accessible to older people and the association of theoretical and practical knowledge.