A simple, selective, rapid, precise, economical, reproducible and stability-indicating UV spectrophotometric method has been developed and validated for determination of Satranidazole in pure form and pharmaceutical dosage form. From solvent effect studies and the spectral behaviour of Satranidazole, methanol was selected as solvent. The UV spectrum was scanned between 200 to 400 nm and 318 nm was selected as maximum wavelength for absorption. Beer's law was obeyed in the concentration range of 2-30 µg /mL. The regression coefficient was 0.999. The method was validated for accuracy, precision, specificity and robustness, in accordance with ICH guidelines. Recovery studies gave satisfactory results indicating that none of common additives and excipients or the degraded impurities interfere in the assay method. Statistical analysis proved the method was precise, reproducible, selective, specific, and accurate for analysis of Satranidazole. Stability testing study includes the effect of oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH values. The wide linearity range, accuracy and easy preparation of diluent imply the method is suitable for routine quantification of Satranidazole in the quality control of bulk forms and pharmaceutical dosage forms with high precision and accuracy.
The present study was aimed to investigate the delivery potential of vancomycin containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of Soya PC: Span 80 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Average vesicle size of optimized formulation F9 was 158.85 nm. The Zeta potential was found 38.25%. Entrapment efficiency of optimized Niosome formulation (F9) was found as 78.85%. Further, niosomes were incorporated into gel base and characterized for viscosity, % entrapment, extrudability, spreadability and drug release study. It was found that viscosity of prepared gel was 3310±25 cps, % assay was 98.95±0.2 %, extrudability was 175±4 g and spreadibility (g/cm/sec) was found that 8.56±0.25 (g/cm/sec) respectively. In vitro drug release from niosome gel was carried out using franz diffusion cell method. The percentage drug release of optimized formulation was found to be 96.65±0.14 after 12 hrs.
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