Providing universal access to cART is the main aim of national programs. It is high time that these programs focus on fertility issues of PLWHA. Reproductive rights of PLWHA need to be respected. Physicians and HIV counselors should proactively discuss and address reproductive issues of PLWHA.

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Background & objectives: Vaccination against COVID-19 induces spike protein-binding IgG antibodies, a robust correlate of protection against COVID-19. This study was undertaken to assess the humoral response after completion of both the doses of ChAdOx1 nCoV vaccine in healthcare workers (HCWs) at a tertiary care health centre in India. Methods: A cross-sectional COVID-19 vaccine-induced antibody study was conducted among HCWs. IgG antibodies against spike protein were measured at least 28 days after the first dose and the second dose of vaccination in both SARS CoV-2 naïve and recovered HCWs. Mean and median antibody titre following each dose of vaccine and its association with age, gender, co-morbidities and factors such as exercise, stress and sleep deprivation were also explored. Results: Among the 200 vaccine recipients, 91.5 per cent showed seroconversion after the first dose and 99.5 per cent after the second dose. The mean titre after the second dose was significantly higher when compared to the first dose (12.68±4.17 vs . 9.83±6.3, P =0.001). More than half (54%) had high antibody titre ≥12 S/Co (Signal/cut-off). Previous COVID-19 infection was the single most important factor influencing antibody production, where the mean titre just after a single dose [mean-17.81±5.94, median-20.5 (interquartile range [IQR]-3.7)] surpassed the titre after the second dose in SARS CoV-2 naïve individuals [mean-12.29±4.00, median-12.8 (IQR-3.7), P =0.001]. Furthermore, 28 per cent of vaccinees showed a reduction in titre after the second dose. The mean fall in titre was 2.25±1.40 and was more pronounced in males, the younger age group and those with previous COVID-19 infection. Interpretation & conclusions: ChAdOx1 nCov-19 vaccine after two doses elicited an excellent immune response. However, greater immunogenicity after the first dose was seen among those with previous COVID-19 infection, even surpassing the titre achieved by the second dose of vaccine in SARS CoV-2 naïve recipients. A fall in antibody titre after the second dose is a matter of concern and requires further studies.

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(p<0.05), TC, TG, TNFR-2, sCD14 (p<0.05) increased in DN and ART than HC. Cardiac output (p<0.001) decreased, TNFR-1 (p=NS), TNFR-2 (p<0.001), sCD14 (p<0.001) higher in DN than ART. No significant difference in C-IMT between groups based on nadir CD4 counts. In naive patients, increased cardiac output (p<0.001), decreased TNFR-1 (p<0.001), TNFR-2 (p<0.001) and sCD14 (p<0.001) was seen in group 2 than group 1. We did not identify statistically significant difference in LP, cardiac output, TNFR-1, TNFR-2, sCD14 levels between groups 3-5. We identified significant correlation (p<0.05) between low CD4 count and increase in C-IMT on ART patients. Conclusion: From clinical perspective, no significant betterment in terms of decrease in inflammatory response, C-IMT and increase in cardiac output was identified during early initiation of ART. However, we found significant increase in inflammatory and MT markers in naive patients with nadir CD4 <350 cells/L than those with higher nadir CD4 count.

Communications between deaf and dumb people and normal people have been a difficult task. The communication is made possible by the help of an interpreter. This project aims to eliminate the need of an interpreter. It is possible because of the invention of hand-talk glove. Hand-talk gloves come equipped with glue sensors and accelerometer. Flex sensors and accelerometer produces different values for different sign languages used by physically challenged people. A PIC identifies the symbols after processing the sensor values. The output is displayed on LCD display. A text-to-speech converter is also used to convey the message more efficiently.

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