One-pot synthesis has become an important subject of modern synthetic chemistry owing to its efficiency, versatility and expediency in constructing complicated polycyclic ring systems, especially with a sustainable and catalytic aspect. This review aims to highlight the recent advances in this area with specific emphasis on the asymmetric synthesis of natural products and related core structures as well as medicinal drugs via one-pot operation. 1 Introduction 2 Double Reactions 3 Triple Reactions 4 Quadruple Reactions 5 Pot-Economy Reactions 6 Conclusions
To a magnetically stirred solution of the diquinane 5c,j 9 (120 mg, 0.63 mmol) in dry benzene (5 mL) was added ethylene glycol (0.07 mL, 1.26 mmol) and a catalytic amount of p-TSA and the resultant reaction mixture was refluxed for 2 h using a Dean-Stark water separator. Saturated NaHCO 3 solution (5 mL) was added to the reaction mixture and extracted with ether (3 x 4 mL). The ether extract was washed with brine (5 mL) and dried (Na 2 SO 4). Evaporation of the solvent and purification of the residue on a silica gel column using ethyl acetate-hexane (1:19) as an eluent furnished the ketal 16 (135 mg, 92%) as
A concise and enantioselective synthesis of the tetracyclic indoles, including the naturally occurring compounds (+)-arborescidine C and (+)-arborescidine B, was achieved by the key step of Pictet-Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst. The synthetic process was further demonstrated in a pot-economy strategy and was achieved in a one-pot operation.
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