This study supports claims in the homeopathic literature on the role of Rhus tox and its ultra dilutions in the treatment of arthritis and associated pain. Further study is needed to explain this anti-arthritic effect of Rhus tox.
Objective: The objective of the study was to compare various herbal cosmetic brands to find their popularity ranking.
Methodology: The method used is a survey-based questionnaire.
Results: According to the above survey conducted in Kanpur regarding herbal products, we came across the following result that Himalaya was the most popular brand as compared to other brands like Patanjali and Joves and other similar brands.
Conclusion: There is not at all shortage in the demand for herbal products in the market. The consumers concern toward health risk and harmful effect of chemical products forcing them to switch over to natural products. There is high favorability of Himalaya products among its users.
Objective:To study the effect of oleanolic acid (OA) on streptozotocin induced diabetic nephropathy in Sprague Dawley rats.Materials and Methods:Four weeks after intra-peritoneal injection of streptozotocin (STZ; 55 mg/kg), the rats with proteinuria were grouped as: Control (non-diabetic, treated orally with vehicle), diabetic control (treated orally with vehicle) and three diabetic groups receiving 20, 40 and 60 mg/kg/day oral doses of OA. At the end of 8 weeks, urine and serum samples from the rats were processed for determination of creatinine, BUN and GFR. The kidney samples were processed for determination of weight changes, oxidative stress related parameters like catalase, superoxide dismutase and reduced glutathione levels. A part of one kidney from each rat was used for transmission electron microscopy (TEM).Result:As evident in TEM, OA inhibited the nephropathy induced alterations in podocyte integrity, basement membrane thickness and spacing between the podocytes at 60 mg/kg dose. It increased GFR and reduced oxidative stress in the kidneys in a dose dependent manner. These findings conclusively demonstrate the efficacy of OA in diabetic nephropathy. Significant decrease in the oxidative stress in kidneys indicates the role of anti-oxidant mechanisms in the effects of OA. However, OA is known to act through multiple mechanisms like inhibition of the generation of advanced glycation end products and improving the insulin secretion. These mechanisms might have contributed to its efficacy.Conclusion:These results conclusively demonstrate the efficacy of OA in diabetic nephropathy through its possible antioxidant activity.
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