A 3-week treatment at Avène Hydrotherapy Centre provided significant and persisting improvement of QoL and clinical symptoms in patients with inherited ichthyoses.

This study demonstrates the positive effects of Avène hydrotherapy on the skin of patients suffering from chronic dermatosis, with decreased inflammation and reduced colonization by S. aureus.

This study investigated the efficacy of post-treatment hydrotherapy as supportive care for management of persistent/long-lasting dermatologic adverse events (dAEs) induced in breast cancer survivors by adjuvant therapy, and its impact on quality of life (QoL).Patients in complete remission after standardised (neo)adjuvant chemotherapy, surgery and radiotherapy combination treatment for infiltrating HR+/HER2-breast carcinoma were enrolled in this randomised, multicentre controlled study 1-5 weeks after completing radiotherapy. The control group (CG, n = 33) received best supportive care and the treatment group (HG, n = 35) received 3-weeks of specific hydrotherapy. The primary criterion was change in QoL (QLQ-BR23) after hydrotherapy. Clinical grading of dAEs, cancer-related QoL (QLQ-C30), dermatologic QoL (DLQI) and general psychological well-being (PGWBI) were assessed. Significant dAEs were found at inclusion in both groups (n = 261). Most items showed significantly greater improvement in the HG

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Background: Acne often results in permanent, badly tolerated, difficult to treat scars. Objective: To evaluate the efficacy and safety of a 0.1% retinaldehyde/6% glycolic acid (RALGA) cream at preventing and treating acne scarring in patients previously treated for moderate acne. Methods: A double-blind vehicle-controlled study was conducted in 145 patients randomized to apply RALGAor vehicle cream every evening for 3 months. Global scarring score and patient’s assessment of global efficacy, then residual acne lesions, quality of life and tolerance were evaluated at inclusion and each month until study completion. Results: Global scarring score, number of inflammatory lesions and comedones significantly improved in each group from day 28 (p < 0.0001). Number of inflammatory lesions were significantly decreased only in the RALGA group. RALGA cream was more efficient than vehicle on scarring after 3 months in compliant patients (p = 0.007) due to erythema and hyperpigmentation improvement. Conclusion: RALGA cream is efficient at preventing and treating acne scarring in patients with moderate acne.

Background: Retinaldehyde and glycolic acid are both efficient in acne. Objective: To evaluate the efficacy and tolerability of a 0.1% retinaldehyde/6% glycolic acid combination (Diacnéal^®) for mild to moderate acne vulgaris. Methods: Overall physician and patient ratings of acne symptom severity and tolerance were performed at baseline, months 1, 2 and 3. Results: Mean numbers of papules, pustules and comedones were significantly reduced from month 1 onwards. A significant advantage of Diacnéal over vehicle was demonstrated on the percentages of patients with ongoing healing lesions at month 2, healing ancient lesions from month 1 and patients with ‘important/very important’ global improvement from month 2 (50.0 vs. 26.3%) confirmed by patients at month 3 (86.1 vs. 58.8%). Products were well tolerated; only 1 patient had to stop the treatment. Conclusions: Diacnéal, a combination of 0.1% retinaldehyde/6% glycolic acid, is effective and well tolerated in mild to moderate acne vulgaris.

Skin ageing is caused by the combination of intrinsic and extrinsic factors leading to the continuous formation of reactive oxygen species (ROS), [1] which induce physiological and structural changes in the skin. UV radiation, potent generator of skin ROS, can upset the balance between pro-oxidants production and antioxidant defense and can therefore directly promote oxidative DNA damage and the peroxidation of lipids and proteins in the skin. [2] This contributes to related oxidative stress skin conditions, including photoallergy, [3] photoageing [4] and photocarcinogenesis. [5] The type of ROS generated depends on the UV wavelength: UVB mainly stimulates the production of O − 2 through the activation of NADPH oxidase and respiratory chain reactions, while UVA produces 1 O 2 through a photosensitizing reaction with internal chromophores such as riboflavin and porphyrin. UVA also generates O − 2