Exposure to harsh environmental conditions, such as cold and dry
climate and chemicals can have an abrasive effect on skin. Skin
care products containing ingredients that avert these noxious
effects by reinforcement of the barrier function can be tested
using in vivo models. The objective is to use in vivo models to
assess the efficacy of emollients in protecting skin against
climatic and chemical insults. A first model used a stream of
cooled air to mimic cold wind. A second used sodium lauryl sulfate
(SLS) under patch as chemical aggressor. In the model with
simulated wind exposure, the untreated exposed area had a
significant decrease in hydration. In contrast, application of an
emollient caused a significant increase in hydration that was
maintained after wind exposure. In the second model with SLS
exposure, application of a barrier cream before SLS patch
significantly reduced the dehydrating effect of SLS with a
significant difference in variation between both areas.
Application of the cream reduced TEWL, indicative of a physical
reinforcement of the skin barrier. The two presented test methods,
done under standardized conditions, can be used for evaluation of
protective effect of emollient, by reinforcing the barrier
function against experimentally induced skin dehydration.
Facial sagging is a major aging change that affects the overall shape of the face. Sagging can negatively impact self-perception and consequently quality of life. In order to fight against this aging sign, we developed a combination of three active ingredients: Tetrahydroxypropyl Ethylenediamine (THPE), Ononis Spinosa extract and Glycerin. In a clinical study, we assessed the efficacy of this association on facial sagging and wrinkles, with a special focus on immediate and lasting effects. Thirty-nine women applied the tested product daily during an eight-week treatment period. Clinical grading by experts and a new, easy to operate, 2-D imaging method were performed at different time points. The 2-D imaging method measured the upper eyelid lifting effect. The results showed an immediate and significant improvement in sagging and wrinkle parameters; these benefits were still observed seven hours after the first application. Results also showed a significant long-term improvement. The lifting effect calculated from the 2-D pictures was 1.08 mm immediately after application; the same method showed a 1.80 mm lifting effect following the eight-week treatment period. These results suggest that a skin care product combining THPE, Ononis Spinosa and Glycerin properties may be used to reduce sagging as well as wrinkles with both immediate and long term benefits.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.