Carrasco, Ling, and Read (2004) reported that involuntary attention increased perceived contrast. We replicated Carrasco et al. and then tested an alternative hypothesis: With stimuli near threshold, a peripheral cue biased observers to believe a stimulus had been presented in the cued location. Consistent with this hypothesis, the effect disappeared when we used higher-contrast stimuli. We further tested the guessing-bias hypothesis in three ways: (1) In a detection experiment, the cue affected bias, but did not increase d ; (2) when the cue followed the stimulus, we obtained the same results as when the cue preceded the stimulus; (3) in one experiment, some trials contained no stimulus, yet observers responded that the cued blank stimulus had higher contrast than the uncued blank stimulus. The results suggest that the effects of a noninformative peripheral cue are best described in terms of nonperceptual biases.

Fear promotes adaptive responses to threats. However, when the level of fear is not proportional to the level of threat, maladaptive fear-related behaviors characteristic of anxiety disorders result. Post-traumatic stress disorder develops in response to a traumatic event, and patients often show sensitized reactions to mild stressors associated with the trauma. Stress-enhanced fear learning (SEFL) is a rodent model of this sensitized responding, in which exposure to a 15-shock stressor nonassociatively enhances subsequent fear conditioning training with only a single trial. We examined the role of corticosterone (CORT) in SEFL. Administration of the CORT synthesis blocker metyrapone prior to the stressor, but not at time points after, attenuated SEFL. Moreover, CORT co-administered with metyrapone rescued SEFL. However, CORT alone without the stressor was not sufficient to produce SEFL. In these same animals, we then looked for correlates of SEFL in terms of changes in excitatory receptor expression. Western blot analysis of the basolateral amygdala (BLA) revealed an increase in the GluA1 AMPA receptor subunit that correlated with SEFL. Thus, CORT is permissive to trauma-induced changes in BLA function.

Background Life altering anxiety disorders, such as post-traumatic stress disorder (PTSD), can co-occur at high rates with substance use disorders. Alcoholism, compared to other substance use disorders, is particularly common. Rodent studies of acute stress effects on alcohol consumption show stress can alter ethanol (EtOH) consumption. This study examined voluntary EtOH consumption in male Long-Evans rats that had undergone a stress-enhanced fear learning (SEFL) procedure. Methods Adult Long-Evans rats were exposed to a stress that consisted of 15 inescapable foot-shocks (1 mA, 1 sec) known to cause a long-lasting non-associative enhancement of subsequent fear learning. Control animals received no shock. One day later, animals were placed in a novel and very different context and received a single foot-shock. On day 3, animals were returned to the single shock context and freezing was used as a measure of learned fear. The intermittent access two-bottle choice (2BC) regimen, consisted of 1 bottle of water and 1 bottle of experimental solution, either 19% EtOH or 28.4% sucrose-0.08% quinine, for a 24 hr period, 3 days a week, and all other times 2 water bottles. This regimen lasted until stable levels of experimental solution drinking were reached, at which point the experimental solution was removed for 40 days and then returned to measure resumption of consumption. Results Rats that received stress prior to ethanol consumed significantly more EtOH than control rats before and after reinstatement. Rats that received stress after drinking was established did not consume significantly more EtOH when the drug was returned. Stress had no significant effect on sucrose-quinine drinking, our calorie and taste control for EtOH. Conclusions A single traumatic event sufficient to produce long-lasting enhancement of fear-learning increases voluntary EtOH consumption, but does not alter previously acquired EtOH drinking habits or alter consumption of a calorically equivalent sweet-bitter tasting solution.