<i>Streptomyces</i> are bacteria of great importance for several decades. Numerous potent metabolites characterized as antibiotics including macrolides and polypetides have been reported from <i>Streptomyces</i> and developed as effective drugs for the treatment of several illnesses. Therefore, <i>Streptomyces</i> can be considered as an important source of bioactive compounds which might help in the eradication of malaria which remains one of the greatest threats to human life, especially in the tropical and sub-tropical regions. The reported in vitro antiplasmodial properties of chemical constituents from <i>Streptomyces</i> strains have led to promising results like bafilomycin A1 (<b>9</b>), concanamycin A (<b>10</b>), elaiophylin (<b>17</b>), cyclomarin C (<b>23</b>), urdamycinone E (<b>44</b>), geldanamycin (<b>52</b>) and metacycloprodigiosin (<b>74</b>) which individually exhibited strong antiplasmodial activity against the chloroquine-resistant strain <i>Plasmodium falciparum</i> K1 with IC<sub>50</sub> values of 0.041 μg/ml, 0.2 nM, 0.22 μg/ml, 0.24 μg/ml, 0.0534 μg/ml, 0.35 μg/ml and 0.0050 μg/ml, respectively. In some cases, the tested compound was most active than the reference and without observed toxicity until the highest concentration. However, more in vivo and toxicity studies are necessary for further guidance in the process of drug development. To the best of our knowledge, no specific review has been done on the potential of <i>Streptomyces</i> in furnishing antiplasmodial compounds for malaria control. This paper aims to compile the literature up to 2021 on antiplasmodial compounds isolated from Streptomyces for easy and rapid access to the literature for further investigations in continuity.
Aridanin, a triterpenoid N-acetylglycoside has been obtained from chemical investigations of the root of <i>Tetrapleura tetraptera</i>, a well-known seasoning spice from Cameroonian food. The structure of the compound has been established using its NMR data and by comparison of that data with the one reported in the literature. Further evidence has been compiled from literature and discussed on the occurrence, the extraction, isolation and analytical techniques as well as the reported biological activities of aridanin. Based on its potency and its high yield in <i>Tetrapleura tetraptera</i> fruits, the compound can be considered as lead compound in the development of medicine for the control of schistosomiasis and bacterial infections caused by the bacterial strains<i>E. coli</i>, <i>E. smartii</i> and <i>E. aeroginese</i>. this paper sheds light on the compound aridanin which deserves more attention in the development of a new potent drug or on the formulation of <i>Tetrapleura tetraptera</i> for effective use by the local population.
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