Background Epithelial-myoepithelial carcinomas are rare neoplasms usually arising from the salivary glands. There is limited evidence in the literature on their prognosis in the base of the tongue but other cases have resolved without recurrence. Methods The patient underwent biopsies demonstrating the diagnosis of epithelial-myoepithelial carcinoma of the base of tongue and a PET scan showed multiple bilateral rounded pulmonary nodules. Results The patient declined chemotherapy and radiotherapy to maximise his quality of life and passed away under management from palliative care several months later. Discussion This is the only case in the literature of this type of carcinoma in the base of the tongue resulting in metastases and a poor prognosis. The case highlights the importance of checking for metastases in such lesions and their potentially serious outcomes if left untreated.
abscess. The initial biopsy was diagnosed as a myxoid tumour with the possibility of an aggressive angiomyxoma noted as difficult to exclude in the biopsy. Subsequent radical excision of the vulva revealed a lesion that was comprised of bland spindle cells showing a 'tissue culture' architecture with extravasated red blood cells. The specimen was sent for fluorescent in situ hybridisation (FISH) analysis which showed USP6 gene rearrangement, confirming the diagnosis of nodular fasciitis.
Conclusion:In the vulva where nodular fasciitis rarely arises, the molecular analysis for USP6 rearrangement is a useful ancillary test in establishing the diagnosis of nodular fasciitis. 2 References 1. WHO Classification of Tumours Editorial Board. WHO Classification of Tumours of Soft Tissue and Bone. 5th ed. Lyon: IARC, 2020; 49-51. 2. Sekulic SP, Sekulic M. Nodular fasciitis of the vulva: a challenging histopathologic diagnosis supported by the detection of USP6 gene rearrangement.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.