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The aim of the present study is to develop a polymer (Guar Gum)-based matrix tablet (using quercetin as a model drug) with sufficient mechanical strength, and promising in vitro mouth-to-colon release profile. By definition, an oral colonic delivery system should retard drug release in the stomach and small intestine, and allow complete release in the colon. By drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing, and fewer systemic side effects. Quercetin is antioxidant in nature and used to treat colon cancer, but they have poor absorption in the upper part of the gastrointestinal tract (GIT). As a site for drug delivery, the colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time, and an increased responsiveness to absorption enhancers. By achieving a colon-targeted drug delivery system, the absorption of quercetin may be increased, which leads to better bioactivity in fewer doses.

Juice of wheat (Triticum aestivum L., Poaceae) grass is termed as green blood. Wheatgrass is a variety of grass that is used like a herbal medicine for its therapeutic and nutritional properties. The aim of this study is to concise the health benefits of green blood therapy. As wheatgrass juice (WGJ) bears a close resemblance to the "hemoglobin" in our blood, the juice is called as "green blood" and the therapy using it is called as "green blood therapy". The WGJ is a complete food and contains carbohydrates, proteins, all essential minerals, and vitamins. Wheatgrass therapy is recommended for patients suffering from chronic diseases such as asthma, atherosclerosis, Parkinson's disease, joint pains, TB, constipation, hypertension, diabetes, bronchitis, insomnia, eczema, sterility, hemorrhage, obesity, and flatulence. It is also useful in the treatment of cancer. The WGJ is immediately absorbed into the bloodstream and gives energy. On an empty stomach, it is assimilated into blood in about 20 min. The energy lasts throughout the day. It is practically a fountain of youth and found to have numerous health benefits. This review is concluded that the WGJ has higher degree of curative index and this can be last alternative therapy when the all therapy will fail. 16  ContraindicationsWheatgrass is contraindicated in those who are hypersensitive to any component of a wheatgrass containing supplement. Adverse reactionsThe WGJ is safe and the incidence of side effects is very low. It may cause nausea and headache if excessive quantities are taken. Throat swelling may occur in hyper sensitive to individuals.

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Background and Objectives: Thyroid disorders are very common in the general population, and it is second only to diabetes as the most common condition to affect the endocrine system. In this study, we try to observe the prevalence of the type of thyroid dysfunction in patients with type 2 diabetes mellitus (T2DM). and its effect on glycemic parameters and the prevalence of autoimmune thyroid disorder in patients with T2DM. Settings and Design: This study included adults having T2DM. Patients were explained about the nature of the study and consent was obtained. Materials and Methods: Clearance was taken from the ethics committee. All participants who met the inclusion criteria were subjected to detailed clinical examination and relevant investigation. Statistical Analysis: Chi-square test was used for the analysis. Results: Two hundred and thirty-four patients (112 males and 122 females) were included in the study. The mean body mass index was high (26.21 ± 3.13 kg/m2). The mean hemoglobin (Hb) A1c was 8.81% ± 1.96%, whereas mean HbA1c in patients with both T2DM and thyroid dysfunction was 9.68% ± 1.35%. Thyroid dysfunction was found in 84 cases (35.8%), out of which the most common thyroid abnormality was overt hypothyroidism (61.9%) followed by subclinical hypothyroidism (27.3%). Out of 84 cases with thyroid dysfunction anti-thyroid peroxidase (TPO) was found positive in 45 cases (53.5%), and the most common thyroid dysfunction associated with positive anti-TPO was subclinical hypothyroidism (44%). Conclusions: The study shows a high prevalence of thyroid dysfunction among patients with T2DM and its association with poor glycemic control. The study also shows the prevalence of anti-TPO among patients and its significant correlation with thyroid dysfunction.